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NCOA5 is correlated with progression and prognosis in luminal breast cancer.

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机构： [1]Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China [2]Department of Oncology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China [3]Cancer Centre, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, PR China

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关键词： NCOA5 Luminal breast cancer Prognosis

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Nuclear receptor coactivator 5 (NCOA5) is known to modulate ERα-mediated transcription and has been found to be involved in the progression of several malignancies. However, the potential correlation between NCOA5 and clinical outcome in patients with luminal breast cancer remains unknown. In the present study, we demonstrated that NCOA5 was significantly up-regulated in luminal breast cancer tissues compared with adjacent non-cancerous tissues both in validated cohort and TCGA cohort. Moreover, Kaplan-Meier analysis indicated that patients with high NOCA5 expression had significantly lower overall survival (P = 0.021). Cox regression analysis indicated that the high NOCA5 expression was independent high risk factor as well as old age (>60) and HER-2 expression (P = 0.039; P = 0.003; P = 0.005; respectively). This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored. Copyright © 2016 Elsevier Inc. All rights reserved.

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出版当年[2016]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

第一作者：

第一作者机构： [1]Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China

通讯作者：

通讯机构： [2]Department of Oncology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejian, PR China [*1]Department of Oncology, First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou, 325000, Zhejiang, PR China.

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