机构：[1]Digestive Department, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China[2]Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China[3]Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, China[4]Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China[5]Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China[6]Liver Tumor Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
Drug resistance to sorafenib is common in patients with hepatocellular carcinoma(HCC). We examined the effects of a combination of sorafenib and fluvastatin on HCC using in vitro and in vivo models. The dual treatment induced apoptosis and reduced cellular viability in HCC more effectively than either drug alone. The combination treatment also inhibited activation of hepatic stellate cells, whereas single drug treatments did not. On a molecular level, combined treatment inhibited activation of the MAPK and NF-κB pathways via Toll-like receptor 4 in HCC cells. Combined treatment also inhibited expression of stromal cell-derived factor 1α in HCC cells, which further inhibited the MAPK pathway in hepatic stellate cells. These results suggest that a combination of sorafenib and fluvastatin may be a promising therapeutic strategy for patients with advanced HCC.
基金：
This work was supported by the Postdoctoral Research Funding of Guangzhou Women and Children’s Medical Center [5001-2150172], the Guangdong Natural Science Foundation [2016A030310254], China Postdoctoral Science Foundation [2016M600648] and National Natural Science Foundation [81602646].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|1 区医学
小类|2 区细胞生物学2 区肿瘤学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Digestive Department, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China[2]Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Cheng,RongCheng Luo,Hang Zheng,et al.Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma.[J].Oncotarget.2017,8(14):23265-23276.doi:10.18632/oncotarget.15575.
APA：
Yang Cheng,RongCheng Luo,Hang Zheng,Biao Wang,YaHui Liu...&Yun Zhu.(2017).Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma..Oncotarget,8,(14)
MLA：
Yang Cheng,et al."Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma.".Oncotarget 8..14(2017):23265-23276
医学