机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.[2]Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.[3]Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.中山大学附属第二医院
Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industry and medicine for a long time. However, little is known about the effects of DHM on ovarian cancer and the underlying mechanisms. In this study, we demonstrated that DHM could effectively inhibit the proliferation of ovarian cancer cells and induce cell apoptosis. Survivin, an inhibitor of apoptosis (IAPs) family member, exhibited a decreased expression level after DHM treatment, which may be attributed to the activation of p53. Moreover, DHM markedly sensitized paclitaxel (PTX) and doxorubicin (DOX) resistant ovarian cancer cells to PTX and DOX by inhibiting survivin expression. Collectively, our findings highlight a previously undiscovered effect of DHM, which induces apoptosis and reverses multi-drug resistance against ovarian cancer cells through downregulation of survivin.
基金：
This study was supported by the Macao Science and Technology Development Fund (062/2013/A2), the Research
Fund of the University of Macau (MYRG2014-00033-ICMS-QRCM, MYRG2014-00051-ICMS-QRCM,
MYRG2015-00171-ICMS-QRCM), and the National Natural Science Foundation of China (81403120).
第一作者机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yingqi Xu,Shengpeng Wang,Hon Fai Chan,et al.Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/srep46060.
APA：
Yingqi Xu,Shengpeng Wang,Hon Fai Chan,Huaiwu Lu,Zhongqiu Lin...&Meiwan Chen.(2017).Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin..SCIENTIFIC REPORTS,7,
MLA：
Yingqi Xu,et al."Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.".SCIENTIFIC REPORTS 7.(2017)
