机构：[1]Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou 510250, China[2]Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China[3]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China[4]Guangdong Province Key Laboratory of Proteomics, Southern Medical University, Guangzhou 510515, China
Atopic dermatitis (AD) is a common inflammatory skin disease with high rates of morbidity and is associated with erythema, pruritus, scaling of affected areas of skin. It is extremely important to introduce a therapeutic agent which has significant anti-inflammatory effect with less side-effect for treatment of AD. This study evaluated the effect of a natural compound from herbal extracts, the crude polysaccharide extracted from the white wax scale (CWPS), on AD-like mice. Repeated applications of 2,4-dinitrochlorobenzene (DNCB) were performed on ear and dorsal skin of BALB/c mice to induce AD-like symptoms and skin lesions. Oral administration of CWPS decreased serum IgE level and limited the infiltration of mast cells and eosinophils to the dermal tissues in the DNCB-induced AD mice. In addition, CWPS reduced Th1 and Th17 responses, leading to an attenuated cutaneous inflammatory response. Furthermore, in vitro study also demonstrated that CWPS limited T cell activation and cytokines (i.e. IFN-γ and IL-17) production induced by DNCB. We conclude that CWPS attenuates DNCB-induced AD-like skin lesion through modulating T cell-elicited immune responses and CD4+ T cell polarization, and could be exploited as a new therapeutic approach for AD.
基金：
Science and Technology
Planning Project of Guangdong Province 2011B031800106 (to L.
S.), Develop project of Distinguished Young Teacher in Southern
Medical University (to L.S.), Foundation for Distinguished Young
Teacher in Higher Education of Guangdong Yq2013034 (to D.Z.),
Science and Technology Planning Project of Guangdong Province
2016A020215106 (to D.Z.), and Science and Technology Planning
Project of Guangzhou 201607010195 (to D.Z.).
第一作者机构：[1]Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou 510250, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China[4]Guangdong Province Key Laboratory of Proteomics, Southern Medical University, Guangzhou 510515, China[*1]Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
推荐引用方式(GB/T 7714)：
Lin Lin,Zhou Yiwei,Li Huifang,et al.Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice.[J].SAUDI PHARMACEUTICAL JOURNAL.2017,25(4):625-632.doi:10.1016/j.jsps.2017.04.035.
APA：
Lin Lin,Zhou Yiwei,Li Huifang,Pang Dejian,Zhang Liyun...&Sun Ledong.(2017).Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice..SAUDI PHARMACEUTICAL JOURNAL,25,(4)
MLA：
Lin Lin,et al."Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice.".SAUDI PHARMACEUTICAL JOURNAL 25..4(2017):625-632
