机构：[1]School of Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China[2]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China[3]Institute of Biomedicine, Department of Cellular Biology, Guangdong Province Key Lab of Bioengineering Medicine, Jinan University, Guangzhou, Guangdong 510632, China[4]College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China
Ruyan Neixiao Cream (RYNXC) is a traditional Chinese herbal formula for treating mammary precancerous disease. This study was carried out to investigate in vivo anticancer effect of RYNXC and multiple constituents. 32 virginal Sprague-Dawley rats were randomly divided into blank control group (BC), mammary precancer models group (MODEL), tamoxifen group (TAM), and Ruyan Neixiao Cream group (RYNXC). TAM was intervened by tamoxifen; RYNXC was intervened by Ruyan Neixiao Cream. The chromatographic separation was performed by high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). RYNXC showed significant improvement in erythrocyte aggregation index (EAI), hematocrit (HCT), fibrinogen (FIB), spleen coefficient, and uterus coefficient compared with MODEL. In RYNXC and TAM groups, atypical hyperplasia was observed in pathological mammary tissues; meanwhile in MODEL group, ductal carcinoma was observed in situ. Moreover, fifteen compounds were characterized according to HPLC-MS data, including organic acids, tannin, alkaloid, volatile oil, anthraquinones, and flavonoids. The study suggests that RYNXC was an effective Chinese herbal formula for mammary precancerous lesions and provides a scientific basis for the quality standard and the pharmacology of RYNXC. It will be beneficial to the future clinical application of RYNXC.
基金：
National Natural Science Foundation of China (nos. 81673979, 81173265,
81473688, and 81373314), the Education Program of China
for New Century Excellent Talents (no. NCET-13-0827),
the Traditional Chinese Medicine Administration Project of
Guangdong, China (no. 20141070), the Science and Technology Program of Guangzhou, China (no. 2014J4100104), the
Science and Technology Program of Guangdong, China (nos.
2014A020212672, 2014A020210015, and 2013B090500105), the
Research Cultivation and Innovation-Medical Joint Foundation of Jinan University, Guangzhou, China (no. 21615464),the Natural Science Foundation of Guangdong, China
(nos. 2016A030313114 and 2015A030313333), and Guangzhou
Municipal Enterprise Research and Development Institutions
Construction Project (no. 201503010064).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|3 区全科医学与补充医学
最新[2025]版：
无
第一作者：
第一作者机构：[1]School of Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Ruixue,Zhang Guijuan,Ma Yi,et al.Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions.[J].Evidence-based complementary and alternative medicine : eCAM.2017,2017:6235027.doi:10.1155/2017/6235027.
APA：
Chen Ruixue,Zhang Guijuan,Ma Yi,Bie Fengjie,Fan Hongxia&Ma Min.(2017).Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions..Evidence-based complementary and alternative medicine : eCAM,2017,
MLA：
Chen Ruixue,et al."Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions.".Evidence-based complementary and alternative medicine : eCAM 2017.(2017):6235027
