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Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice.

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收录情况： ◇ SCIE

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机构： [a]GMH Institute of CNS Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases,Jinan University, Guangzhou 510632, China [b]Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy, Jinan University, Guangzhou 510632, China [c]Department of Immunobiology, Instituteof Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China [d]State Key Disciplineof Infectious Diseases, Department of Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen518112, China

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关键词： Zeaxanthin dipalmitate Non-alcoholic steatohepatitis chronic hepatitis B HBV transgenic mice protective effect

摘要：

A hepatitis B virus (HBV) transgenic mice model was used to establish the fatty liver superimposed model by feeding the methionine choline-deficient (MCD) diet for 8 weeks, with or without the gavage of 2 mg/kg zeaxanthin dipalmitate (ZD) three times per week. Both wild-type and HBV transgenic mice, with MCD diet, gained typical non-obese non-alcoholic steatohepatitis (NASH) and HBV symptoms. Coadministration with ZD exhibited evident therapeutic effects through alleviating those pathological events. Moreover, long-term vehicle-ZD treatment was found to be safe. Thus, ZD is a promising and safe hepato-protective agent against hepatic injury induced by superimposed HBV and NASH in non-obese mice.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

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出版当年[2015]版：

Q3 PLANT SCIENCES Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 1.3 最新[2023版] 1.5 最新五年平均 1.009 出版当年[2015版] 1.028 出版当年五年平均 0.913 出版前一年[2014版] 1.071 出版后一年[2016版]

第一作者：

第一作者机构： [a]GMH Institute of CNS Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases,Jinan University, Guangzhou 510632, China

通讯作者：

通讯机构： [c]Department of Immunobiology, Instituteof Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China [d]State Key Disciplineof Infectious Diseases, Department of Infectious Diseases, Shenzhen Third People’s Hospital, Shenzhen518112, China

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