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pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery.

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收录情况： ◇ EI

作者：
Jian-Tao Lin[a,b] * ; Ji-Kun Du[c] * ; Yi-Qiu Yang[d] ; Li Li[b] ; Da-Wei Zhang[d] ; Cui-Ling Liang[d] ; Jie Wang[d] ; Jun Mei[d] ; Guan-Hai Wang[d] ;
机构： [a]Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 523024, China [b]Traditional Chinese Medicine and New Drug Research Institute, Guangdong Medical University, Dongguan 523808, China [c]Department of Clinical Laboratory, Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University, Shenzhen, China [d]School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
出处：
DOI： 10.1016/j.msec.2017.08.036
ISSN：

摘要：
In this work, we developed a drug-conjugated nanocarrier with "zero premature release" property for actively targeted drug delivery. The pH and redox dual-responsive nanocarrier was fabricated based on hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was conjugated to MSNs via hydrazone bonds, which can be cleaved in tumor tissue (acidic conditions). To improve specific cellular uptake and stability of nanocarriers, HA was equipped with an outer shell on the nanoparticle surface via a disulfide crosslinker. Stimulus-induced release of the DOX was studied in the different pH and GSH, which showed the embedded DOX can be controlled release from MSN channels. The dual-triggered drug release system provides an efficient targeted drug delivery system into the cytosol of cancer cells. The results of flow cytometry and confocal laser scanning microscopy (CLSM) showed that the HA-functionalized DOX-conjugated nanoparticles presented much better cellular uptake and higher cytotoxicity to tumor cells. This drug delivery system has great potential for tumor-trigged drug release for cancer therapy. Copyright © 2017. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (81402563), Traditional Chinese Medicine Bureau Foundation of Guangdong Province (20141158), Special Foundation for Young Innovation Scientists of Department of Education of Guangdong Province (2014KQNCX097 and 2014KQNCX098), Training Plan for Outstanding Young Teachers in Higher Education Institutions of Guangdong Province (YQ2015083) and Student Innovation Training Program (4CX16048G).
语种：
外文
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中科院(CAS)分区：
出版当年[2016]版：
大类 | 2 区 工程技术
小类 | 3 区 材料科学：生物材料
最新[2025]版：
无
第一作者：
第一作者机构： [a]Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 523024, China [b]Traditional Chinese Medicine and New Drug Research Institute, Guangdong Medical University, Dongguan 523808, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Jian-Tao Lin,Ji-Kun Du,Yi-Qiu Yang,et al.pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery.[J].Materials science & engineering, C. Materials for Biogical applications.2017,doi:10.1016/j.msec.2017.08.036.
APA：
Jian-Tao Lin,Ji-Kun Du,Yi-Qiu Yang,Li Li,Da-Wei Zhang...&Guan-Hai Wang.(2017).pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery..Materials science & engineering, C. Materials for Biogical applications,,
MLA：
Jian-Tao Lin,et al."pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery.".Materials science & engineering, C. Materials for Biogical applications .(2017)

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