机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Public Health, Guangdong Medical University, Zhanjiang, China,[2]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China,[3]Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States,[4]Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, United States,[5]Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, China
Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-κB-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.
基金：
This study was supported by the Macao Science and Technology
Development Fund (080/2016/A2 and 126/2016/A3), the
Research Fund of University of Macau (MYRG2016-00143-
ICMS-QRCM and MYRG2016-00031-ICMS-QRCM), the
National Natural Science Foundation of China (Nos: 81603066,
81470170, and 81273166), the International Technology
Cooperation Projects of Dongguan (20135081520017), the
Features Innovative Projects of Key Platform andMajor Scientific
Research Project of Universities in Guangdong Province
(2015KTSCX048), and the Technology Plan Projects of Medical
and Health Science in Dongguan City (201605101290). Wen-An
Qiang was partially supported by NU-PSOC (U54 CA193419)
and Robert H. Lurie Comprehensive Cancer Center OncoSET
initiatives at the Northwestern University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区药学
最新[2025]版：
大类|3 区医学
小类|3 区药学
第一作者：
第一作者机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Public Health, Guangdong Medical University, Zhanjiang, China,[2]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China,
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Public Health, Guangdong Medical University, Zhanjiang, China,[2]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China,
推荐引用方式(GB/T 7714)：
Zhang-Feng Zhong,Hai-Bing Yu,Chun-Ming Wang,et al.Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism.[J].Frontiers in pharmacology.2017,8:648.doi:10.3389/fphar.2017.00648.
APA：
Zhang-Feng Zhong,Hai-Bing Yu,Chun-Ming Wang,Wen-An Qiang,Sheng-Peng Wang...&Yi-Tao Wang.(2017).Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism..Frontiers in pharmacology,8,
MLA：
Zhang-Feng Zhong,et al."Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism.".Frontiers in pharmacology 8.(2017):648
