Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities.
机构：[1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People’s Republic of China[2]State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, People’s Republic of China[3]Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, 510632, People’s Republic of China.
Phyllomeroterpenoids A-C (1-3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4-9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1-3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).
基金：
National Natural Science Foundation of China (81422054
and 81373306), the Guangdong Natural Science Funds for Distinguished Young Scholar (S2013050014287),
Guangdong Special Support Program (2016TX03R280), Guangdong Province Universities and Colleges Pearl
River Scholar Funded Scheme (Hao Gao, 2014), Pearl River Nova Program of Guangzhou (201610010021), K.
C. Wong Education Foundation (Hao Gao, 2016), the Open Fund of State Key Laboratory of Pharmaceutical
Biotechnology of Nan-jing University (KF-GN-201412), and "Challenge Cup" National Undergraduate Curricular
Academic Science and Technology Works of Jinan University (16112034).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People’s Republic of China[2]State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, People’s Republic of China
推荐引用方式(GB/T 7714)：
Yang Heng-Gang,Zhao Huan,Li Jiao-Jiao,et al.Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities.[J].Scientific reports.2017,7(1):12925.doi:10.1038/s41598-017-13407-y.
APA：
Yang Heng-Gang,Zhao Huan,Li Jiao-Jiao,Chen Shao-Meng,Mou Lang-Ming...&Gao Hao.(2017).Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities..Scientific reports,7,(1)
MLA：
Yang Heng-Gang,et al."Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities.".Scientific reports 7..1(2017):12925
