机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China[2]Department of Gastrointestinal Surgery, Shunde First People’s Hospital, Southern Medical University, Guangdong 528300, China[3]Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China[4]Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China
This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria. In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria. The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS. We further confirmed in vitro, and what is more, we found that APS may ameliorate mitochondrial dysfunction through Sirt1 pathway. Based on the results, we may figure out part of the molecular mechanism of mitochondrial amelioration by APS.
基金：
National Science
Foundation of China (no. 81373808).
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China[2]Department of Gastrointestinal Surgery, Shunde First People’s Hospital, Southern Medical University, Guangdong 528300, China[3]Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China[4]Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China[3]Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China[4]Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China
推荐引用方式(GB/T 7714)：
Huang Yan-Feng,Lu Lu,Zhu Da-Jian,et al.Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress.[J].OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.2016,2016:doi:10.1155/2016/9573291.
APA：
Huang Yan-Feng,Lu Lu,Zhu Da-Jian,Wang Ming,Yin Yi...&Wei Lian-Bo.(2016).Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress..OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2016,
MLA：
Huang Yan-Feng,et al."Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress.".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016.(2016)
