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Bilateral Common Carotid Artery Occlusion in Spontaneously Hypertensive Rats: A Feasible Animal Model for Ocular Ischemic Syndrome.

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机构： [1]Department of Ophthalmology, the Fourth Hospital of Shijiazhuang, Shijiazhuang, HebeiProvince 050011, China [2]Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou,Guangdong Province 510080, China [3]Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang,Hebei Province 050000, China [4]Department of Imaging and Interventional Radiology, Prince of Wales Hospital, theChinese University of Hong Kong, Shatin, New Territories, Hong Kong, China [5]Department of Gastroenterology, the Second Hospital of Hebei Medical University, HebeiKey Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang,Hebei Province 050000, China [6]Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China [7]Department of Ophthalmology, the Second Hospital of Hebei Medical University,Shijiazhuang, Hebei Province 050000, China [8]Department of Medicine, Shenzhen University Health Science Centre, Shenzhen 518060,China

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The purpose of this study was to investigate the feasibility of inducing ocular ischemic syndrome in spontaneously hypertensive rats. Hypertensive and normotensive Wistar-Kyoto rats had bilateral occlusion or sham surgery. They were divided into 4 groups: (1) hypertensive-ischemia, (2) hypertensive-sham, (3) normotensive-ischemia, and (4) normotensive-sham. Four months after the operation, the global changes of the eye and pupillary light reflex were assessed. Then each rat was perfused, and randomly one of the bulbuses oculi was prepared as retinal flat mounts for investigation of vascular changes. The opposite eyeball was prepared as a paraffin section for observation of the linear density of retinal ganglion cells and for thickness measurement. One hypertensive-ischemia rat had a cataract in one eye and another rat in the same group had bulbus oculi collapse in one eye. The light reflex disappeared in 13.33% of hypertensive-ischemia rats, and the rest of the hypertensive-ischemia rats and normotensive-ischemia rats had slow reflex. Compared with the respective controls, the peripheral retinal vascular network in hypertensive-ischemia and normotensive-ischemia rats was sparse; linear density of the retinal ganglion cells was significantly reduced; and the retinal thickness was reduced. Compared with normotensive-ischemia rats, the hypertensive-ischemia rats demonstrated more severe changes. After bilateral common carotic artery occlusion, the eyes of hypertensive rats developed various pathological changes similar to those of ocular ischemic syndrome. In conclusion, an animal model for ocular ischemic syndrome can be created by bilateral common carotid artery occlusion in spontaneously hypertensive rats. Anat Rec, 299:806-814, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区解剖学与形态学

最新[2025]版：

大类 | 4 区医学

小类 | 3 区解剖学与形态学

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出版当年[2014]版：

Q2 ANATOMY & MORPHOLOGY

最新[2023]版：

Q2 ANATOMY & MORPHOLOGY

影响因子： 1.8 最新[2023版] 2 最新五年平均 1.542 出版当年[2014版] 1.666 出版当年五年平均 1.53 出版前一年[2013版] 1.507 出版后一年[2015版]

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第一作者机构： [1]Department of Ophthalmology, the Fourth Hospital of Shijiazhuang, Shijiazhuang, HebeiProvince 050011, China

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通讯作者：

通讯机构： [7]Department of Ophthalmology, the Second Hospital of Hebei Medical University,Shijiazhuang, Hebei Province 050000, China [8]Department of Medicine, Shenzhen University Health Science Centre, Shenzhen 518060,China [*1]Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China. [*2]Department of Medicine,Shenzhen University Health Science Centre, Shenzhen 518060, China

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