机构：[1]Institue of Allergy and Immunology, School of Medicine, Shen Zhen University,[2]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University,[3]Department of Rheumatism, Traditional Chinese Medicine, The Sixth People’s Hospital of Shenzhen City, Shenzhen, China深圳市康宁医院深圳医学信息中心
Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction.
In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant.
We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model.
In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats.
The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.
基金：
Natural Science
Foundation of China (No. 81300292 to B.Y. and No.81271950 to
QM.J.), Guangdong Foreign Scientifi c Technology Cooperative
Project (No. 2013B051000088 to ZG.L.), and Shenzhen Scientific
Techology Basic Research Projects (No. 005177 to QM.J.,
JCYJ20140418095735538 to ZG.L., JCYJ20130402151227168 to
SG.H.).
语种：
外文
被引次数：
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Institue of Allergy and Immunology, School of Medicine, Shen Zhen University,
共同第一作者：
通讯作者：
通讯机构：[1]Institue of Allergy and Immunology, School of Medicine, Shen Zhen University,[2]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University,[*1]Rm722, School of Medicine Building, Shenzhen University, Nan Hai Avenue 3688, Shenzhen, China.
推荐引用方式(GB/T 7714)：
Li Jianjie,Yan Hao,Chen He,et al.The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy.[J].NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES.2016,8(1):40-46.doi:10.4103/1947-2714.175206.
APA：
Li Jianjie,Yan Hao,Chen He,Ji Qiongmei,Huang Shengguang...&Yang Bo.(2016).The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy..NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES,8,(1)
MLA：
Li Jianjie,et al."The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy.".NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES 8..1(2016):40-46
