The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis.
机构：[1]Postdoctoral Workstation of Chinese and Western Integrative Medicine, School of Medicine, Jinan University, Guangzhou,Guangdong, China[2]The Futian Affiliated Hospital of Guangdong Medical Institute, Shenzhen, Guangdong, China[3]The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China深圳市第二人民医院深圳医学信息中心[4]Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China[5]Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China[6]Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University,Guangzhou, Guangdong, China[7]Department of Orthopedic Surgery, Hunan Provincial Hospital of Traditional Chinese Medicine, Zhuzhou, Hunan, China
Objective. To evaluate the efficacy and safety of the total glucosides of peony (TGP) and leflunomide (LEF) for the treatment of rheumatoid arthritis (RA). Methods. Randomized controlled trials (RCTs) on the efficacy and safety of the combination of TGP and LEF versus LEF alone for the treatment of RA were retrieved by searching PubMed, EMBASE, Cochrane Library, the China National Knowledge Infrastructure database, and Wanfang database. Results. Eight RCTs including 643 RA patients were included in the present meta-analysis. The quality of included studies was poor. The levels of ESR (P < 0.0001), CRP (P < 0.0001), and RF (P < 0.0001) in RA patients who received the combination of TGP and LEF were significantly lower than RA patients who received LEF therapy alone. The pooled results suggest that the combination of TGP and LEF caused less abnormal liver function than LEF alone (P = 0.02). No significant difference in the gastrointestinal discomfort was identified between the combination of TGP and LEF and LEF alone groups (P = 0.18). Conclusion. The combination of TGP and LEF in treatment of RA presented the characteristics of notably decreasing the levels of laboratory indexes and higher safety in terms of liver function. However, this conclusion should be further investigated based on a larger sample size.
基金：
This project was supported by grants from the National Natural Science Foundation of China (no. 81273665), National
High Technology Research and Development Program
(no. 2014AA020907), the Key Project of Shenzhen Science and Technology Program (no. JCYJ20130401115547212),
the Guangdong Provincial Natural Science Foundation
(2015A030310067), and Shenzhen Technology Innovation
Foundation (no. JCYJ20150401171352927).
第一作者机构：[1]Postdoctoral Workstation of Chinese and Western Integrative Medicine, School of Medicine, Jinan University, Guangzhou,Guangdong, China[2]The Futian Affiliated Hospital of Guangdong Medical Institute, Shenzhen, Guangdong, China[3]The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China[4]Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China
通讯作者：
通讯机构：[2]The Futian Affiliated Hospital of Guangdong Medical Institute, Shenzhen, Guangdong, China[3]The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China[4]Shenzhen Institute of Geriatrics, Shenzhen, Guangdong, China
推荐引用方式(GB/T 7714)：
Zhitao Feng,Juan Xu,Guochao He,et al.The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis.[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2016,2016:doi:10.1155/2016/9852793.
APA：
Zhitao Feng,Juan Xu,Guochao He,Meiqun Cao,Lihong Duan...&Zhengzhi Wu.(2016).The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis..EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,
MLA：
Zhitao Feng,et al."The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis.".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2016.(2016)
