Additive Effect of Qidan Dihuang Grain, a Traditional Chinese Medicine, and Angiotensin Receptor Blockers on Albuminuria Levels in Patients with Diabetic Nephropathy: A Randomized, Parallel-Controlled Trial.
机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China[2]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity,Guangzhou, Guangdong 510515, China..[3]Endocrinology Department, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China[4]Second Chinese Medicine Hospital of Guangdong, Guangzhou, Guangdong 510095, China.[5]First People’s Hospital of Baiyun District, Guangzhou, Guangdong 510410, China.
Albuminuria is characteristic of early-stage diabetic nephropathy (DN). The conventional treatments with angiotensin receptor blockers (ARB) are unable to prevent the development of albuminuria in normotensive individuals with type 2 diabetes mellitus (T2DM). Purpose. The present study aimed to evaluate the effect of ARB combined with a Chinese formula Qidan Dihuang grain (QDDHG) in improving albuminuria and Traditional Chinese Medicine Symptom (TCMS) scores in normotensive individuals with T2DM. Methods. Eligible patients were randomized to the treatment group and the control group. Results. Compared with baseline (week 0), both treatment and control groups markedly improved the 24-hour albuminuria, total proteinuria (TPU), and urinary albumin to creatinine ratio (A/C) at 4, 8, and 12 weeks. Between treatment and the control group, the levels of albuminuria in the treatment group were significantly lower than in the control group at 8 and 12 weeks (p < 0.05). In addition, treatment group markedly decreased the scores of TCMS after treatment. Conclusion. This trial suggests that QDDHG combined with ARB administration decreases the levels of albuminuria and the scores for TCMS in normotensive individuals with T2DM.
基金：
State Administration of Traditional Chinese
Medicine (no. JDZX2012013), the National Science Foundation
of China (nos. 81173146, 81403447, and 81573812), China
Postdoctoral Science Foundation (no. 2014M552187), and the
Science & Technical Plan of Guangzhou, Guangdong, China
(no. 2014Y2-00504).
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China[2]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity,Guangzhou, Guangdong 510515, China..
共同第一作者：
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China[2]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity,Guangzhou, Guangdong 510515, China..
推荐引用方式(GB/T 7714)：
Xiang Lei,Jiang Pingping,Zhou Lin,et al.Additive Effect of Qidan Dihuang Grain, a Traditional Chinese Medicine, and Angiotensin Receptor Blockers on Albuminuria Levels in Patients with Diabetic Nephropathy: A Randomized, Parallel-Controlled Trial.[J].EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2016,2016:doi:10.1155/2016/1064924.
APA：
Xiang Lei,Jiang Pingping,Zhou Lin,Sun Xiaomin,Bi Jianlu...&Liu Yanyan.(2016).Additive Effect of Qidan Dihuang Grain, a Traditional Chinese Medicine, and Angiotensin Receptor Blockers on Albuminuria Levels in Patients with Diabetic Nephropathy: A Randomized, Parallel-Controlled Trial..EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2016,
MLA：
Xiang Lei,et al."Additive Effect of Qidan Dihuang Grain, a Traditional Chinese Medicine, and Angiotensin Receptor Blockers on Albuminuria Levels in Patients with Diabetic Nephropathy: A Randomized, Parallel-Controlled Trial.".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2016.(2016)
