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Astragaloside IV alleviates E. coli-caused peritonitis via upregulation of neutrophil influx to the site of infection.

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机构： [1]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China [2]Department of Microbiology and Immunology, Guangdong Pharmaceutical University, Guangzhou 510006, China [3]Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China [4]Intensive Care Unit, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China [5]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China

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关键词： Astragaloside IV Peritonitis Neutrophils Migration CXCR2

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Astragaloside IV (AS-IV), an active saponin purified from Astragali Radix, has been identified with broad biological and pharmacological activities. In the present study, we continue to explore the potential effect of AS-IV on antibacterial response using an acute E. coli peritoneal infection model. Our findings implied that administration of AS-IV decreases mortality in mice challenged by lethal E. coli infection. The protection of AS-IV was related to promotion of neutrophil extravasation into the peritoneum and bacterial clearance. Toll-like receptor (TLR) activation in neutrophils has been reported to reduce CXCR2 expression and subsequent neutrophil migration. Our data indicated that AS-IV prevented the reduction of CXCR2 expression and neutrophil migration induced by LPS, the activator for TLR4. Moreover, we found that AS-IV blocks LPS-induced suppression of CXCR2 on neutrophils by inhibiting the expression of G protein-coupled receptor kinase-2 (GRK2), an agonist that regulates desensitization and internalization of chemokine receptors. Taken together, these data propose that AS-IV, through modulating GRK2-CXCR2 signal in neutrophils, offers an essential efficacy on host antibacterial immunity. Copyright © 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区药学 4 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

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第一作者机构： [1]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China [2]Department of Microbiology and Immunology, Guangdong Pharmaceutical University, Guangzhou 510006, China

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通讯机构： [2]Department of Microbiology and Immunology, Guangdong Pharmaceutical University, Guangzhou 510006, China [3]Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China [*1]Department ofMicrobiology and Immunology, Guangdong Pharmaceutical University, Guangzhou 510006, China

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