机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.[2]Divisions of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.[3]Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.[4]Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, Guangdong, China.[5]Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Rotaviruses are known to recognize human histo-blood group antigens (HBGAs) as a host ligand that is believed to play an important role in rotavirus host susceptibility and host range. In this study, paired fecal and saliva samples collected from children with viral gastroenteritis, as well as paired serum and saliva samples collected from the general population in south China were studied to evaluate potential association between rotavirus infections and human HBGA phenotypes. Rotavirus was detected in 75 (28%) of 266 fecal samples and P[8] rotaviruses were found to be the predominant genotype. The HBGA phenotypes of the rotavirus-infected children were determined through their saliva samples. Secretor statuses were found to correlate with the risk of rotavirus infection and all P[8]/P[4] rotavirus infected children were secretors. Accordingly, recombinant VP8* proteins of the P[8]/P[4] rotaviruses bound saliva samples from secretor individuals. Furthermore, correlation between serum P[8]/P[4]-specific IgG and host Lewis and secretor phenotypes has been found among 206 studied serum samples. Our study supported the association between rotavirus infection and the host HBGA phenotypes, which would help further understanding of rotavirus host range and epidemiology.
基金：
This work was supported by the National Natural Science Foundation of China (81473402), the Natural Science
Foundation of GuangDong Province (2014A030313332), Collaborative innovation major projects-science and
technology project of Guangzhou (201604020111) and Scientific research initiation plan of Southern Medical
University (QD2015N006 and CX2015N001).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu-Fu Zhang,Yan Long,Ming Tan,et al.P[8] and P[4] Rotavirus Infection Associated with Secretor Phenotypes Among Children in South China.[J].Scientific reports.2016,6:34591.doi:10.1038/srep34591.
APA：
Xu-Fu Zhang,Yan Long,Ming Tan,Ting Zhang,Qiong Huang...&Ying-Chun Dai.(2016).P[8] and P[4] Rotavirus Infection Associated with Secretor Phenotypes Among Children in South China..Scientific reports,6,
MLA：
Xu-Fu Zhang,et al."P[8] and P[4] Rotavirus Infection Associated with Secretor Phenotypes Among Children in South China.".Scientific reports 6.(2016):34591
