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Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.

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机构： [1]Department of Traditional Chinese Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [2]The Key Laboratory of Molecular Biology,State Administration of Traditional Chinese Medicine,School of Traditional Chinese Medicine, Southern Medical University,Guangzhou 510515,China [3]Traditional Chinese Medicine Integrated Hospital,Southern Medical University,Guangdong,Guangzhou 510305,China

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Danzhi Xiaoyao San (DXS) is a canonical Chinese medicine formula from Principles of Internal Medicine, which was written during the Ming dynasty. This formula is approved and commercialized for use in the prevention and treatment of affective disorders. This study is aimed to investigate the hypothesis that DXS treats depressive-like behavior by shifting the balance of the kynurenine (Kyn)/serotonin (5-HT) pathway toward the 5-HT pathway through the downregulation of hippocampal indoleamine 2,3-dioxygenase (IDO). Chemical fingerprints of gardenoside, paeoniflorin, ferulic acid, paeonol, and ligustilide in standard extraction were used as the material bases of DXS. Rats with depressive-like behavior induced by chronic unpredictable mild stress (CUMS) were randomly divided into four groups, namely the control, model, DXS, and fluoxetine groups. Cytokines, IDO, and tryptophan (Trp) catabolites were analyzed by enzyme-linked immunosorbent assay, western blot, and liquid chromatography-electrospray ionization tandem mass spectrometry, respectively. DXS significantly increased crossing grid numbers, sucrose consumption, and body weight. This treatment significantly decreased the serum levels of tumor necrosis factor-α and interleukin 6 (IL-6). However, DXS elicited no significant effects on IL-1β, IL-2, and interferon γ. DXS downregulated the activity of IDO and subsequent production of Kyn in the hippocampus. This treatment upregulated the hippocampal contents of Trp and 5-HT but did not influence 5-HT turnover. DXS exhibited antidepressant-like effects on rats exposed to CUMS. DXS reduced IDO activity to shift the balance of the Kyn/5-HT pathway toward the 5-HT pathway. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 2 区全科医学与补充医学 3 区药物化学 3 区药学 3 区植物科学

最新[2025]版：

大类 | 2 区医学

小类 | 1 区全科医学与补充医学 1 区药学 2 区药物化学 2 区植物科学

第一作者：

第一作者机构： [1]Department of Traditional Chinese Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [2]The Key Laboratory of Molecular Biology,State Administration of Traditional Chinese Medicine,School of Traditional Chinese Medicine, Southern Medical University,Guangzhou 510515,China

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通讯机构： [1]Department of Traditional Chinese Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [2]The Key Laboratory of Molecular Biology,State Administration of Traditional Chinese Medicine,School of Traditional Chinese Medicine, Southern Medical University,Guangzhou 510515,China [*1]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

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