机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China[2]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Millions of individuals are vaccinated worldwide each year to stimulate their adaptive immune systems to produce protective antibodies and T-cell response against pathogens. Since glycosylation of the Fc region of immunoglobulin G (IgG) can be influenced by the host's immune status, it was inferred that glycosylation profile of IgG might be altered as a result of the immune response. Therefore, subclass-specific glycosylation profiles of serum IgGs from 26 healthy adults before and after vaccination with a trivalent subunit influenza virus vaccine were comprehensively analyzed to explore glycomic signatures for vaccination. The results showed that no significant changes in the glycosylation of total IgGs took place before and after vaccination, but distinct glycosylation profiles in responders (fourfold or more increase of HI titer after vaccination) and nonresponders (less than fourfold increase of HI titer) were observed. This difference between the responders and nonresponders occurred even in the resting state. On the basis of variable importance parameters, glycosylation markers that distinguish responders from nonresponders were identified. These markers can be used as molecular signatures to predict antibody titers after vaccination. This is the first study of serum IgG glycosylation profiles in healthy adults receiving a trivalent inactivated influenza vaccine.
基金：
This project is sponsored by Macao Science and Technology Development Fund (020/2013/
A1 to J.Z.H.) and financially supported by Emergency Response Project of Ministry of
Science and Technology of China (Grant no.KJYJ-2013-01-05), National Science and
Technology Major Project of the Ministry of Science and Technology of China (Grant no.
2014ZX10004006).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China[2]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
推荐引用方式(GB/T 7714)：
Wang Jing-Rong,Guan Wen-Da,Yau Lee-Fong,et al.Glycomic signatures on serum IgGs for prediction of postvaccination response.[J].Scientific reports.2015,5:7648.doi:10.1038/srep07648.
APA：
Wang Jing-Rong,Guan Wen-Da,Yau Lee-Fong,Gao Wei-Na,Zhan Yang-Qing...&Jiang Zhi-Hong.(2015).Glycomic signatures on serum IgGs for prediction of postvaccination response..Scientific reports,5,
MLA：
Wang Jing-Rong,et al."Glycomic signatures on serum IgGs for prediction of postvaccination response.".Scientific reports 5.(2015):7648
