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Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes.

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机构： [1]Department of Nephrology, the Affiliated Xiaolan Hospital of Southern Medical University, Zhong Shan, China [2]Nephrology Department of the First Hospital Affiliated to Ji’Nan University, Guangzhou, China [3]Guangzhou Medical University, Guangzhou First People’s Hospital, Guangdong Province, China [4]GongAn Hospital of Traditional Chinese Medicine, HuBei, China

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In this study, we investigated the molecule mechanisms of podocyte injury and proteinuria and the protective effects of losartan. This study set up three groups: a control group; an Ang II group (Ang II 10(-6) mol/l, Sigma); and a losartan group (losartan 10(-6) mol/l, Sigma). We used RT-PCR assay to detect TRPC6 mRNA expression, and Western blot to detect TRPC6 protein expression. TRPC6 overexpression was the basic change of podocyte injury and proteinuria occurrence. Losartan can treat podocyte injury and proteinuria induced by Ang II via downregulation of TRPC6 in podocytes. These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases. © The Author(s) 2015.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 4 区外周血管病

最新[2025]版：

大类 | 4 区医学

小类 | 4 区外周血管病

第一作者：

第一作者机构： [1]Department of Nephrology, the Affiliated Xiaolan Hospital of Southern Medical University, Zhong Shan, China

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通讯机构： [2]Nephrology Department of the First Hospital Affiliated to Ji’Nan University, Guangzhou, China

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