机构：[1]Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, China,[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China,[3]Divisions of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America,[4]Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America,[5]Provincial Laboratory for Public Health (ProvLab), Edmonton, Alberta, Canada,[6]Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton,Alberta, Canada
The GII.4 noroviruses (NoVs) are a single genotype that is responsible for over 50% of NoV gastroenteritis epidemics worldwide. However, GII.4 NoVs have been found to undergo antigenic drifts, likely selected by host herd immunity, which raises an issue for vaccine strategies against NoVs. We previously characterized GII.4 NoV antigenic variations and found significant levels of antigenic relatedness among different GII.4 variants. Further characterization of the genetic and antigenic relatedness of recent GII.4 variants (2008b and 2010 cluster) was performed in this study. The amino acid sequences of the receptor binding interfaces were highly conserved among all GII.4 variants from the past two decades. Using serum samples from patients enrolled in a GII.4 virus challenge study, significant cross-reactivity between major GII.4 variants from 1998 to 2012 was observed using enzyme-linked immunosorbent assays and HBGA receptor blocking assays. The overall abilities of GII.4 NoVs to bind to the A/B/H HBGAs were maintained while their binding affinities to individual ABH antigens varied. These results highlight the importance of human HBGAs in NoV evolution and how conserved antigenic types impact vaccine development against GII.4 variants.
基金：
National Institutes of Health of the United States
(R01 AI 055649, R01 AI 37093, R01 AI 089634 and
P01 HD 13021); the Agriculture and Food Research
Initiative Competitive Grants Program of the USDA
National Institute of Food and Agriculture, NIFA
Award No.: 2011-68003-30005; and the National
Natural Science Foundation of China (81473402)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区生物
小类|3 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, China,[3]Divisions of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America,
通讯作者：
通讯机构：[3]Divisions of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America,[4]Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America,
推荐引用方式(GB/T 7714)：
Ying-Chun Dai,Xu-Fu Zhang,Ming Xia,et al.Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.[J].PloS one.2015,10(4):e0124945.doi:10.1371/journal.pone.0124945.
APA：
Ying-Chun Dai,Xu-Fu Zhang,Ming Xia,Ming Tan,Christina Quigley...&Xi Jiang.(2015).Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera..PloS one,10,(4)
MLA：
Ying-Chun Dai,et al."Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.".PloS one 10..4(2015):e0124945
