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Paris Saponin VII Inhibits the Migration and Invasion in Human A549 Lung Cancer Cells.

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资源类型：
Pubmed体系：
作者：
Fan Lei[1,4] * ; Li Yuhua[2] * ; Sun Yang[1] * ; Han Jing[1] ; Yue Zhenggang[1] ; Meng Jin[3] ; Zhang Xutao[1] ; Zhang Feng[1,*2] ; Mei Qibing[1,*1] ;
机构： [1]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Collaborative Innovation Center for Chinese Medicine in Qinba Mountains, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China [2]No. 422 Hospital of PLA, Zhanjiang 524005, Guangdong, PR China [3]Department of Pharmacy, No. 309 Hospital of PLA, Beijing 100009, PR China [4]Department of Pharmacy, No. 210 Hospital of PLA, Liaoning 116000, PR China
出处：
DOI： 10.1002/ptr.5389
ISSN：

摘要：
Metastasis is the main cause of death in lung cancer. Targeting the process of metastasis is a strategy to lung cancer treatment. Trillium tschonoskii Maxim., a traditional Chinese medicine, has been used for treatment of many diseases, including cancer. This study aims to determine the anti-metastatic effect of paris saponin VII (PS VII) which was extracted from T. tschonoskii Maxim. by using human lung cancer cell line A549 cells. Our results showed that PS VII could significantly suppress the viability as well as cell migration and invasion abilities of A549 cells in a concentration-dependent manner. PS VII reduced the activity of matrix metalloproteinase-2 (MMP-2) and MMP-9 by elevating the expression of TIMP1/2. These data indicated that PS VII could reduce the metastatic capability of A549 cells, probably through up-regulating the expression of TIMP1/2. These findings demonstrated a new therapeutic potential for PS VII in anti-metastatic therapy of lung cancer. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

基金：
Taibaishan Natural Preserve of Shaanxi Province, and the grant (No. 81302787) from the National Nature Science Foundation of China, and the grant (Nos. 2012M512102, 2013T60964) from the Postdoctoral Science Foundation of China.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 医学
小类 | 4 区 药物化学 4 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 药物化学 2 区 药学
第一作者：
第一作者机构： [1]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Collaborative Innovation Center for Chinese Medicine in Qinba Mountains, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China [4]Department of Pharmacy, No. 210 Hospital of PLA, Liaoning 116000, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Collaborative Innovation Center for Chinese Medicine in Qinba Mountains, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China [*1]Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, Shaanxi, PR China
推荐引用方式(GB/T 7714)：
Fan Lei,Li Yuhua,Sun Yang,et al.Paris Saponin VII Inhibits the Migration and Invasion in Human A549 Lung Cancer Cells.[J].Phytotherapy research : PTR.2015,29(9):1366-1372.doi:10.1002/ptr.5389.
APA：
Fan Lei,Li Yuhua,Sun Yang,Han Jing,Yue Zhenggang...&Mei Qibing.(2015).Paris Saponin VII Inhibits the Migration and Invasion in Human A549 Lung Cancer Cells..Phytotherapy research : PTR,29,(9)
MLA：
Fan Lei,et al."Paris Saponin VII Inhibits the Migration and Invasion in Human A549 Lung Cancer Cells.".Phytotherapy research : PTR 29..9(2015):1366-1372

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