详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Influence of Resting-State Network on Lateralization of Functional Connectivity in Mesial Temporal Lobe Epilepsy.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]College of Mechatronics and Automation,National University of Defense Technology, Changsha, Hunan, People’s Republic of China [2]Department of Medical Imaging, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [3]and Department of Information Engineering, Officers College of Chinese Armed Police Force, Chengdu, Sichuan, China.

出处：

DOI：

ISSN：

摘要：

Although most studies on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of neurons. Increasingly, studies have indicated that mesial temporal lobe epilepsy may be a network-level disease; however, few investigations have examined resting-state functional connectivity of the entire brain, particularly in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. This study primarily investigated whole-brain resting-state functional connectivity abnormality in patients with mesial temporal lobe epilepsy and right hippocampal sclerosis during the interictal period. We investigated resting-state functional connectivity of 21 patients with mesial temporal lobe epilepsy with right hippocampal sclerosis and 21 neurologically healthy controls. A multivariate pattern analysis was used to identify the functional connections that most clearly differentiated patients with mesial temporal lobe epilepsy with right hippocampal sclerosis from controls. Discriminative analysis of functional connections indicated that the patients with mesial temporal lobe epilepsy with right hippocampal sclerosis exhibited decreased resting-state functional connectivity within the right hemisphere and increased resting-state functional connectivity within the left hemisphere. Resting-state network analysis suggested that the internetwork connections typically obey the hemispheric lateralization trend and most of the functional connections that disturb the lateralization trend are the intranetwork ones. The current findings suggest that weakening of the resting-state functional connectivity associated with the right hemisphere appears to strengthen resting-state functional connectivity on the contralateral side, which may be related to the seizure-induced damage and underlying compensatory mechanisms. Resting-state network-based analysis indicated that the compensatory mechanism among different resting-state networks may disturb the hemispheric lateralization. © 2015 by American Journal of Neuroradiology.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2014]版：

大类 | 3 区医学

小类 | 2 区神经成像 2 区核医学 3 区临床神经病学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区核医学 3 区临床神经病学 3 区神经成像

第一作者：

第一作者机构： [1]College of Mechatronics and Automation,National University of Defense Technology, Changsha, Hunan, People’s Republic of China [3]and Department of Information Engineering, Officers College of Chinese Armed Police Force, Chengdu, Sichuan, China.

共同第一作者：

通讯作者：

通讯机构： [1]College of Mechatronics and Automation,National University of Defense Technology, Changsha, Hunan, People’s Republic of China [2]Department of Medical Imaging, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [*1]No. 109, Deya Rd, Kaifu District, Changsha City, Hunan Province, People’s Republic of China [*2]First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16 Airport Rd, Guangzhou, Guangdong, 510405, People’s Republic of China

推荐引用方式(GB/T 7714)：

APA：

MLA：