机构：[1]Department of Respiratory, The First Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China中山大学附属第一医院[2]Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China中山大学附属第一医院[3]Respiratory Department, Nanchang Hospital of Integrative Traditional Chinese and Western Medicine, Jiangxi University of Traditional Chinese Medicine Nanchang, Jiangxi, People’s Republic of China .
CUE domain-containing 2 (CUEDC2) is a multi-functional protein, which regulates cell cycle, growth factor signaling and inflammation. We found that CUEDC2 was low in lung adenocarcinoma cell lines and lung adenocarcinoma tissues at both mRNA and protein levels. Low levels of CUEDC2 were correlated with a shorter survival time in patients with lung adenocarcinoma (p = 0.004). CUEDC2 expression was correlated with tumor T classification (P = 0.001) at clinical stage (P = 0.001) and tumor size (P = 0.033). Multivariate analysis suggested that CUEDC2 expression is an independent prognostic indicator for patients with lung adenocarcinoma. Ectopic expression of CUEDC2 decreased cell proliferation in vitro and inhibited tumor growth in nude mice in vivo. Knockdown of endogenous CUEDC2 by short hairpin RNAs (shRNAs) increased tumor growth. Inhibition of proliferation by CUEDC2 was associated with inactivation of the PI3K/Akt pathway, induction of p21 and down-regulation of cyclin D1. Our results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
基金：
Science and Technology Planning Project of Guangdong Province, China (2009 B03081171); The Science and Technology Planning Project of Guangzhou Science and Technology Council (09A7d2060166); The Natural Science Funds of Guangdong Province (No.2014A030310167); The Natural Science Foundation in China(NSFC) (81460444 to Longhua Sun).
第一作者机构：[1]Department of Respiratory, The First Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China[3]Respiratory Department, Nanchang Hospital of Integrative Traditional Chinese and Western Medicine, Jiangxi University of Traditional Chinese Medicine Nanchang, Jiangxi, People’s Republic of China .
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推荐引用方式(GB/T 7714)：
Sun Longhua,Bai Lihong,Lin Gengpeng,et al.CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.[J].ONCOTARGET.2015,6(24):20685-20696.doi:10.18632/oncotarget.3930.
APA：
Sun Longhua,Bai Lihong,Lin Gengpeng,Wang Ran,Liu Yangli...&Xie Canmao.(2015).CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma..ONCOTARGET,6,(24)
MLA：
Sun Longhua,et al."CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.".ONCOTARGET 6..24(2015):20685-20696
