机构：[1]Traditional Chinese Medicine Integrated Hospital, Southern Medical University,Guangzhou, Guangdong, China[2]The Key Laboratory of Molecular Biology,State Administration of Traditional Chinese Medicine, School of TraditionalChinese Medicine, Southern Medical University, Guangzhou, Guangdong510515, China[3]Nanfang Hospital, Southern Medical University, Guangzhou,Guangdong, China
This study aims to evaluate the efficacy of Xiaoyaosan (XYS) for treatment of major depressive disorder (MDD) and to review the studies on antidepressant mechanisms of XYS.
The China Knowledge Resource Integrated Database (1998-2014), VIP Journal Integration Platform (1989-2009), and PubMed (1950-2014) were used to search for and collect scientific publications related to XYS and MDD. Clinical trials for "MDD" and "xiaoyao" were screened. Papers that used the original prescription of XYS for treatment and in combination with Western medicines were included, while papers describing modified XYS were excluded. Four investigators read and screened the resulting publications independently, evaluated the associated scientific results and evidence.
There were no conclusive results to support the efficacy of XYS for treatment of MDD, owing to limited sample sizes, flaws in blinding and randomization, and lack of multi-centered clinical trials. Among the experimental studies on the effects of XYS possible involvement of 5-hydroxytryptamine, hypothalamic-pituitary-adrenal axis function, and neuroinflammation were possibly involved demonstrated.
The effectiveness of XYS for treatment of MDD is uncertain.
基金：
This work was supported by the National Science Foundation of China
(81230085, 81173168), the Research Program jointly sponsored by the Department
of Science and Technology and the Academy of Traditional Chinese
Medicine of Guangdong Province and the Planned Science (2014A020221011),
Technology Project of Guangzhou, China (12C32121551).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区医学
小类|2 区全科医学与补充医学4 区药学
最新[2025]版：
大类|2 区医学
小类|2 区全科医学与补充医学2 区药学
第一作者：
第一作者机构：[1]Traditional Chinese Medicine Integrated Hospital, Southern Medical University,Guangzhou, Guangdong, China
通讯作者：
通讯机构：[2]The Key Laboratory of Molecular Biology,State Administration of Traditional Chinese Medicine, School of TraditionalChinese Medicine, Southern Medical University, Guangzhou, Guangdong510515, China[3]Nanfang Hospital, Southern Medical University, Guangzhou,Guangdong, China
推荐引用方式(GB/T 7714)：
Jing Lin-Lin,Zhu Xiao-Xia,Lv Zhi-Ping,et al.Effect of Xiaoyaosan on major depressive disorder.[J].Chinese medicine.2015,10:18.doi:10.1186/s13020-015-0050-0.
APA：
Jing Lin-Lin,Zhu Xiao-Xia,Lv Zhi-Ping&Sun Xue-Gang.(2015).Effect of Xiaoyaosan on major depressive disorder..Chinese medicine,10,
MLA：
Jing Lin-Lin,et al."Effect of Xiaoyaosan on major depressive disorder.".Chinese medicine 10.(2015):18
