机构:[1]Department of Oncology, Nanfang Hospital, Guangzhou[2]Department of Oncology, Traditional Chinese Medicine-Integrated Hospital[3]Cancer Research Institute, Southern Medical University, Guangzhou[4]Department of Oncology, Changzhou No.2 People’s Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou[5]Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China
Previous studies have reported the association between excess body mass index (BMI) and increased risk of hepatocellular carcinoma (HCC). However, whether BMI is associated with the prognosis and postoperative complications of HCC is still not clear.We searched PubMed and Embase for relevant studies published until the date of August 30, 2014. Additional studies were manually identified by searching reference lists of retrieved articles. Pooled hazard ratios (HRs) with 95% confidence intervals (95% CIs) for overall survival (OS), disease-free survival (DFS), and risk ratios (RRs) with 95% CIs for postoperative complications were calculated using random effects or fixed effects models according to heterogeneities between studies.A total of 14 studies were included in the present meta-analysis. The pooled results showed that excess BMI was not significantly associated with improved OS (HR = 0.94; 95% CI: 0.74-1.19, P = 0.588) or DFS (HR = 0.93; 95% CI: 0.79-1.10, P = 0.382). In addition, higher BMI was not associated with increased rate of a number of complications including ascites (RR = 1.25, 95% CI: 0.94-1.65, P = 0.119), bile leaks (RR = 1.22, 95% CI: 0.81-1.83, P = 0.345), and 30-day mortality (RR = 1.05, 95% CI: 0.57-1.96, P = 0.871). However, HCC patients with higher BMI had increased incidence of wound infections (RR = 2.17, 95% CI: 1.28-3.68, P = 0.004).BMI was not an independent prognostic factor for the evaluation of the prognosis in HCC patients, and it was not associated with postoperative complications except for wound infections that as significantly associated with higher BMI scores.
基金:
National Natural Science Foundation of China
(Grand No.81428017 and No.81401874) and Foundation of President
of the Traditional Chinese Medicine-integrated Hospital (Grand
No.1201302009).
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2014]版:
大类|2 区医学
小类|2 区医学:内科
最新[2025]版:
大类|4 区医学
小类|4 区医学:内科
第一作者:
第一作者机构:[1]Department of Oncology, Nanfang Hospital, Guangzhou[2]Department of Oncology, Traditional Chinese Medicine-Integrated Hospital
共同第一作者:
通讯作者:
通讯机构:[2]Department of Oncology, Traditional Chinese Medicine-Integrated Hospital[*1]Southern Medical University, Guangzhou, Guangdong, China
推荐引用方式(GB/T 7714):
Xiaoxiang Rong,Fang Wei,Qian Geng,et al.The Association Between Body Mass Index and the Prognosis and Postoperative Complications of Hepatocellular Carcinoma: A Meta-Analysis.[J].Medicine.2015,94(31):e1269.doi:10.1097/MD.0000000000001269.
APA:
Xiaoxiang Rong,Fang Wei,Qian Geng,Jian Ruan,Hongfen shen...&Rongcheng Luo.(2015).The Association Between Body Mass Index and the Prognosis and Postoperative Complications of Hepatocellular Carcinoma: A Meta-Analysis..Medicine,94,(31)
MLA:
Xiaoxiang Rong,et al."The Association Between Body Mass Index and the Prognosis and Postoperative Complications of Hepatocellular Carcinoma: A Meta-Analysis.".Medicine 94..31(2015):e1269