机构：[1]Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.中山大学附属第二医院[2]Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.中山大学附属第二医院[3]Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China.深圳市中医院深圳医学信息中心[4]Department of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.
It has been widely reported that the CT60 single-nucleotide polymorphism (SNP), which is in the 3'-untranslated region of the cytotoxic T lymphocyte associated 4 (CTLA4) gene, is strongly correlated with certain immune-mediated diseases. The present case-control study aimed to investigate the genetic association between the CT60 SNP within the CTLA4 gene and Graves' disease (GD). A total of 288 patients with GD and 290 control subjects were recruited for the study. The CT60 SNP of the CTLA4 gene was detected by direct DNA sequencing. The results indicated that the frequencies of the GG genotype and G allele in the case group were evidently higher than that in the control group (P=4×10-6 and P=2.9×10-5, respectively). Furthermore, the G/G genotype of the CT60 SNP was associated with an increased risk for GD (odds ratio=2.223). In conclusion, these results suggested that the CT60 SNP is associated with susceptibility to GD. The frequency of the disease-susceptible G allele of CT60 was significantly associated with an increased risk of GD development.
基金：
The study was supported by Guangdong Medical Science and Technology Research Foundation (grant no. A2010166), Guangdong Province Science and Technology Project (grant no. 2011B031800162) and the Key Project of Guangzhou Science and Technology Project (grant no. 2011J4100114).
第一作者机构：[1]Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[4]Department of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.[*1]Department of Immunology, Zhongshan School of Medicine, Sun Yat‑Sen University, 74 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, P.R. China
推荐引用方式(GB/T 7714)：
Fang Weizhen,Zhang Zhixian,Zhang Jin,et al.Association of the CTLA4 gene CT60/rs3087243 single-nucleotide polymorphisms with Graves' disease.[J].BIOMEDICAL REPORTS.2015,3(5):691-696.doi:10.3892/br.2015.493.
APA：
Fang Weizhen,Zhang Zhixian,Zhang Jin,Cai Zhenhua,Zeng Hua...&Huang Junqi.(2015).Association of the CTLA4 gene CT60/rs3087243 single-nucleotide polymorphisms with Graves' disease..BIOMEDICAL REPORTS,3,(5)
MLA：
Fang Weizhen,et al."Association of the CTLA4 gene CT60/rs3087243 single-nucleotide polymorphisms with Graves' disease.".BIOMEDICAL REPORTS 3..5(2015):691-696
