机构：[1]First Clinical School, Southern Medical University, Guangzhou 510515,Guangdong Province, China[2]School of Traditional Chinese Medicine,Southern Medical University, Guangzhou 510515, Guangdong Province,China[3]Zhaoqing Medical College, Zhaoqing 526020, Guangdong Province,China[4]Huarui Hospital, Southern Medical University, Guangzhou 510630,Guangdong Province, China[5]Clinical School of Acupuncture andRehabilitation, Guangzhou University of Chinese Medicine, Guangzhou510405, Guangdong Province, China深圳市中医院深圳医学信息中心
Using functional magnetic resonance imaging (fMRI), we determined brain regions that were activated/deactivated more by acupuncture at Taixi (KI3) than by non-acupoint or sham acupuncture.
A total of 30 healthy volunteers were randomly divided into a KI3 group (15 subjects) and non-acupoint group (15 subjects). Subjects in KI3 group received a sham acupuncture and then a real acupuncture, fMRI was performed before and after sham acupuncture as well as after ture acupuncture. Subjects in non-acupoint group received a ture acupuncture and the fMRI was performed before and after ture acupuncture. The fMRI data obtained were successively analyzed using DPARSF2.3 and REST1.8 software, yielding regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) values.
Compared with sham acupuncture, ALFF values were higher in Brodmann area (BA) 10 and lower in BA7 and BA18. ReHo values after real acupuncture at KI3 were higher in the right sub-lobar region and BA10 and were lower in BA31. Compared with the changes before and after real acupuncture at non-acupoint, the changes at KI3 showed higher ALFF valued in the left cerebellum posterior lobe, BA10, BA39, BA31 and decreased ALFF was observed in the BA18, BA19 and BA40; and higher ReHo values were shown in left cerebellum posterior lobe pyramis, left cerebellum anterior lobe. BA37, BA10, BA39, BA31 and lower ReHo values were shown in BA18 and BA31.
Acupuncture at KI3 has a specific effect on certain brain regions associated with perception, body movement, spirit, and association. Additionally, visual and auditory cortices were affected, which may be related to the clinical applications of KI3 acupuncture in auditory and cognitive disorders, hypomnesis, loss of concentration, and the loss of ability to work and learn.
The research ethics committee was achieved at 01/08/2012, the NO. was ChiECRCT-2012011. Website for Clinical Trial Registration: http://www.chictr.org.cn/showproj.aspx?proj=7123 . This study was registered at www.chictr.org, the Clinical Trial Registration Number was ChiCTR-TRC-12002427, and the registration number was achieved at 18/08/2012. The name of IRB that provided approval for the study and clearly state is Chinese Clinical Trail Registry.
基金：
This study was supported by the National Key Basic Research andDevelopment
Project (973 Program) (Grant no.2012CB518504), the National-level Undergraduate
Student Innovation Venture Training Project of Local Colleges (no.201212121048),
and the Three-stage Key Subject Construction Project of Guangdong Province
ofChina (211 Project) (Grant no. Yuefagaishe (2009) 431).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|3 区全科医学与补充医学
最新[2025]版：
无
第一作者：
第一作者机构：[1]First Clinical School, Southern Medical University, Guangzhou 510515,Guangdong Province, China
共同第一作者：
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推荐引用方式(GB/T 7714)：
Bo Zhu,Yanjie Wang,Guifeng Zhang,et al.Acupuncture at KI3 in healthy volunteers induces specific cortical functional activity: an fMRI study.[J].BMC complementary and alternative medicine.2015,15:361.doi:10.1186/s12906-015-0881-3.
APA：
Bo Zhu,Yanjie Wang,Guifeng Zhang,Huailiang Ouyang,Jiping Zhang...&Chunzhi Tang.(2015).Acupuncture at KI3 in healthy volunteers induces specific cortical functional activity: an fMRI study..BMC complementary and alternative medicine,15,
MLA：
Bo Zhu,et al."Acupuncture at KI3 in healthy volunteers induces specific cortical functional activity: an fMRI study.".BMC complementary and alternative medicine 15.(2015):361
