机构：[1]Departments of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.[2]Departments of Intensive Care Unit, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.[3]Departments of Laboratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.
The aim of the present work was to evaluate the association between the interleukin 10 (IL-10) -3575T/A (rs1800890) polymorphism and cancer risk. We performed a met-analysis based on 15 studies, including 15608 cancer cases and 17539 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association, and performed sensitivity analyses. In the stratified analyses by all included studies, no association between IL-10-3575T/A (rs1800890) polymorphism and cancer risk (OR=0.966, 95% CI=0.889-1.05, P=0.417 for A vs. T; OR=1.035, 95% CI=0.975-1.1, P=0.257 for AA vs. AT+TT; OR=1.008, 95% CI=0.964-1.054, P=0.723 for AA+AT vs. TT) was observed. In the stratified analyses by cancer type of lymphoma and non-lymphoma, no association between them was also detected (Lymphoma: OR=1.021, 95% CI=0.962-1.083, P=0.496 for A vs. T; OR=1.029, 95% CI=0.967-1.095, P=0.363 for AA vs. AT+TT; OR=1.017, 95% CI=0.952-1.086, P=0.626 for AA+AT vs. TT; Non-lymphoma: OR=0.966 95% CI=0.889-1.51, P=0.245 for A vs. T; OR=1.035, 95% CI=0.975-1.1, P=0.287 for AA vs. AT+TT; OR=1.017, 95% CI=0.948-1.091, P=0.967 for AA+AT vs. TT). The results were the same by sensitivity analyses. No publication bias was existed in the analysis. The interleukin 10-3575T/A polymorphism may have no association with cancer risk.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Departments of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.[2]Departments of Intensive Care Unit, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.
共同第一作者：
通讯作者：
通讯机构：[1]Departments of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.[3]Departments of Laboratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Songshan Lake Avenue 22, Dongcheng District, Dongguan 523000, Guangdong, China.[*1]Department of Respiratory Medicine, Dongguan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, 22 Songshan Lake Avenue, Dongcheng District, Dongguan 523000, Guangdong Province, China.
推荐引用方式(GB/T 7714)：
Zhu Biyuan,Xiao Chaolie,Zhu Biqing,et al.Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls.[J].International journal of clinical and experimental medicine.2015,8(8):14335-44.
APA：
Zhu Biyuan,Xiao Chaolie,Zhu Biqing,Zheng Zhiwen&Liang Jingjing.(2015).Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls..International journal of clinical and experimental medicine,8,(8)
MLA：
Zhu Biyuan,et al."Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls.".International journal of clinical and experimental medicine 8..8(2015):14335-44
