机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China[2]Departmentof Epidemiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health andTropical Medicine, Southern Medical University, Guangzhou, Guangdong, China[3]Guangdong Provincial Centerfor Disease Control and Prevention, Guangzhou, China[4]Divisions of Infectious Diseases, Cincinnati Children’s Hospital Medical Center[5]Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio,USA[6]DongGuan Center for Disease Control and Prevention, Dongguan, Guangdong, China
During the past norovirus (NoV) epidemic season, a new GII.17 variant emerged as a predominant NoV strain, surpassed the GII.4 NoVs, causing outbreaks of acute gastroenteritis (AGE) in China. Here we report a study of an AGE outbreak in an elementary school in December 2014 caused by the new GII.17 NoV to explore the potential mechanism behind the sudden epidemics of the GII.17 NoV. A total of 276 individuals were sick with typical NoV infection symptoms of vomiting (93.4%), abdominal pain (90.4%), nausea (60.0%), and diarrhea (10.4%) at an attack rate of 5.7-16.9%. Genotyping of the symptomatic patients showed that individuals with a secretor positive status, including those with A, B, and O secretors and Lewis positive blood types, were sensitive to the virus, while the non-secretors and the Lewis negative individual were not. Accordingly, the recombinant capsid P protein of the GII.17 isolate showed a wide binding spectrum to saliva samples of all A, B, and O secretors. Thus, the broad binding spectrum of the new GII.17 variant could explain its widely spread nature in China and surrounding areas in the past two years.
基金：
This work was supported by the National Natural Science Foundation of China (81473402) and the
Natural Science Foundation of GuangDong Province (2014A030313332). It also partly supported by
science and technology planning project of Guangzhou (2014Y2-00151). Xi Jiang and Ming Tan were
partially supported by a NIH R01 grant (AI089634).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区综合性期刊
小类|2 区综合性期刊
最新[2025]版：
大类|3 区综合性期刊
小类|3 区综合性期刊
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu-Fu Zhang,Qiong Huang,Yan Long,et al.An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility.[J].Scientific reports.2015,5:17687.doi:10.1038/srep17687.
APA：
Xu-Fu Zhang,Qiong Huang,Yan Long,Xi Jiang,Ting Zhang...&Ying-Chun Dai.(2015).An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility..Scientific reports,5,
MLA：
Xu-Fu Zhang,et al."An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility.".Scientific reports 5.(2015):17687
