机构：[1]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China[3]Department of Traditional Chinese Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, Guangdong 510080, China.广东省人民医院[4]Department of Personnel Section, Southern Medical University, Guangdong, Guangzhou 510515, China[5]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.深圳市中医院深圳医学信息中心
Paclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding of its pathophysiology and lack of effective treatments. This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel.
Breast cancer mice established with murine 4 T1 cells were randomly and repectively divided into five groups: negative control group (NC), tumor control group (TC), paclitaxel group (PTX), Bu-Zhong-Yi-Qi pill group (BZYQ) and Bu-Zhong-Yi-Qi pill plus paclitaxel group (BZYQ + PTX). The mice were administered for 21 days. During this period, the tumor volume, body weight and the weight-loaded swimming time were measured. After the last administration, all mice were sacrificed, weighted the tumor, measured immune cell cytokines and oxidative stress indicator. The remaining 10 mice in each group were observed for survival analysis.
Treatments with BZYQ + PTX and PTX significantly reduced the rates of tumor volume in comparison with TC starting on the 9th day and the 18th day respectively (P < 0.05-0.01), and presented decreased tumor weight compared to TC (P < 0.05-0.01). Compared with mice in TC group, the median survival time and the average survival time in BZYQ + PTX group, BZYQ group and PTX group were significantly prolonged (P < 0.05-0.01). The swimming time of the BZYQ + PTX group gradually increased, which is longer than the PTX group on Day 14 and Day 21 (P < 0.01). The level of TNF-α was lower in BZYQ + PTX group than PTX group (P < 0.01). The level of SOD activity in BZYQ + PTX group was lower than the NC group (P <0.01), but much higher than the PTX group (P < 0.01). The level of MDA of BZYQ + PTX group was higher than the NC group (P < 0.01), but significant lower than the PTX group (P < 0.01).
BZYQ has the potential of alleviating paclitaxel chemotherapy-related fatigue in 4 T1 breast cancer mice by reducing the serum levels of TNF-α and modulating the level of MDA and the SOD activity.
基金：
the NSFC-Guangdong joint fund (No. U1132001),
the National Science Foundation of China (Nos. 81173146, 81202622, 81373707,
81302958, 81403340 and 81403347), China Postdoctoral Science Foundation
(Nos. 2014 M552187), the Guangdong Provincial Department of Science and
Technology and Guangdong Provincial Academy of Traditional Chinese Medicine
joint fund (Nos. 2011B032200004, 2012A032500004 and 2013A032500008), the
Guangdong Provincial Department of Science and Technology fund (Nos.
2011B031700018), and the Science & Technical Plan of Guangzhou, Guangdong,
China (Nos. 2011 J4300108)
第一作者机构：[1]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China[5]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China
推荐引用方式(GB/T 7714)：
Ouyang Mingzi,Liu Yanyan,Tan Wei,et al.Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.[J].BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE.2014,14:doi:10.1186/1472-6882-14-497.
APA：
Ouyang Mingzi,Liu Yanyan,Tan Wei,Xiao Ya,Yu Keqiang...&Zhao Xiaoshan.(2014).Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model..BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14,
MLA：
Ouyang Mingzi,et al."Bu-zhong-yi-qi pill alleviate the chemotherapy-related fatigue in 4 T1 murine breast cancer model.".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14.(2014)
