资源类型：
期刊
Pubmed体系：
Journal Article;Research Support, Non-U.S. Gov't
文章类型：
论著
机构：
[1]Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, China
[2]Oncology Department, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
ISSN：
0304-3835
摘要：
Aberrant epidermal growth factor (EGF)-dependent signaling plays a key role in the progression of human carcinomas. We found that TIP30, a tumor suppressor protein, translocated into the nucleus of human lung adenocarcinoma cells following EGF treatment, and the selective inhibitors of EGFR signaling pathways blocked this effect. Chromatin immunoprecipitation assays revealed that TIP30 negatively regulated EGF-dependent transcriptional activation of CCND1 through a HDAC1-dependent mechanism. In lung adenocarcinoma patients, the level of nuclear TIP30 was inversely correlated with that of EGFR and cyclin D1. These findings suggest that nuclear TIP30-induced downregulation of cyclin D1 transcription antagonizes EGFR signaling and suppresses tumorigenesis.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
PubmedID：
25135222
中科院(CAS)分区：
出版当年[2013]版：
大类
|
2 区
医学
小类
|
3 区
肿瘤学
最新[2025]版：
大类
|
1 区
医学
小类
|
2 区
肿瘤学
第一作者：
Shuai Shuai
第一作者机构：
[1]Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, China
共同第一作者：
Yan Xiao
通讯作者：
Luo Rongcheng;Li Aimin
推荐引用方式(GB/T 7714)：
Shuai Shuai,Yan Xiao,Zhang Junyi,et al.TIP30 nuclear translocation negatively regulates EGF-dependent cyclin D1 transcription in human lung adenocarcinoma.[J].Cancer letters.2014,354(1):200-9.doi:10.1016/j.canlet.2014.08.008.
APA：
Shuai Shuai,Yan Xiao,Zhang Junyi,Kang Shijun,Chen Fengsheng...&Li Aimin.(2014).TIP30 nuclear translocation negatively regulates EGF-dependent cyclin D1 transcription in human lung adenocarcinoma..Cancer letters,354,(1)
MLA：
Shuai Shuai,et al."TIP30 nuclear translocation negatively regulates EGF-dependent cyclin D1 transcription in human lung adenocarcinoma.".Cancer letters 354..1(2014):200-9
医学