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Effect of 1,25-dihydroxyvitamin D₃on regulatory T cells in ovariectomized mice.

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机构： [1]Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong, China [2]TheSecond Affiliated Hospital (Jiande Branch), School of Medicine, ZheJiang University, Jiande 311600, Zhejiang,China [3]Institution of Traditional Chinese Medicine and New Pharmacy Development, Guangdong MedicalCollege, Dongguan 523808, Guangdong, China

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关键词： 1 25-dihydroxyvitamin D3 Osteoporosis Regulatory T cells Ovariectomy

摘要：

To investigate the correlation between regulatory T (Treg) cells and postmenopausal osteoporosis and the antiosteoporotic effect of 1,25-dihydroxyvitamin D3 [1,25(OH)₂D₃] in relation to Treg cells. Fifty female BALB/c mice were randomly divided into five groups: the basal control (BAS), Sham, ovariectomy (OVX), OVX+diethylstilbestrol (OVX+DES), and OVX+1,25(OH)₂D₃. Tibias were harvested and processed with decalcification for quantitative bone histomorphometry. Femurs were stained by immunohistochemistry to detect Foxp3 protein expression. Spleens were used to detect Treg and Foxp3 gene expression by flow cytometry and quantitative RT-PCR, respectively. In comparison with the Sham group, a significant decrease was found in the OVX group in such indices as trabecular bone volume/total tissue area (BV/TV), trabecular number (Tb.N) and trabecular thickness (Tb.Th). 1,25(OH)₂D₃and DES partly prevented the decrease in BV/TV, Tb.N, Tb.Th in OVX mice. Treg cell number, Foxp3 mRNA expression in spleen and Foxp3 protein expression in femur significantly decreased in the OVX-treated group compared with those in the sham group. 1,25(OH)2D₃and DES significantly increased Treg cell number and Foxp3 expression. Treg cells and Foxp3 gene expression were related to bone histomorphometric parameters. The decrease in Treg cell numbers is relevant to the postmenopausal osteoporosis. The antiosteoporosis of 1,25(OH)₂D₃is related to regulatory T cells. Copyright © 2014 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

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出版当年[2013]版：

大类 | 4 区环境科学与生态学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

最新[2025]版：

大类 | 4 区医学

小类 | 4 区环境科学 4 区公共卫生、环境卫生与职业卫生

第一作者：

第一作者机构： [1]Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong, China [2]TheSecond Affiliated Hospital (Jiande Branch), School of Medicine, ZheJiang University, Jiande 311600, Zhejiang,China

通讯作者：

通讯机构： [1]Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong, China [3]Institution of Traditional Chinese Medicine and New Pharmacy Development, Guangdong MedicalCollege, Dongguan 523808, Guangdong, China

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