机构：[1]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity, Guangzhou, Guangdong 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China[3]Endocrinology Department, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
To evaluate the effect of Chinese herbal medicine (CHM) on albuminuria levels in patients with diabetic nephropathy (DN), we performed comprehensive searches on Medline database, Cochrane Library, CNKI database, CBM database, Wanfang database, and VIP database up to December 2012. A total of 29 trials including 2440 participants with DN met the selection criteria. CHM was tested to be more effective in reducing urinary albumin excretion rate (UAER) (MD -82.95 μ g/min, [-138.64, -27.26]) and proteinuria (MD -565.99 mg/24 h, [-892.41, -239.57]) compared with placebo. CHM had a greater beneficial effect on reduction of UAER (MD -13.41 μ g/min, [-20.63, -6.19]) and proteinuria (MD -87.48 mg/24 h, [-142.90, -32.06]) compared with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB). Combination therapy with CHM and ACEI/ARB showed significant improvement in UAER (MD -28.18 μ g/min, [-44.4, -11.97]), urinary albumin-creatinine ratio (MD -347.00, [-410.61, -283.39]), protein-creatinine ratio (MD -2.49, [-4.02, -0.96]), and proteinuria (MD -26.60 mg/24 h, [-26.73, -26.47]) compared with ACEI/ARB alone. No serious adverse events were reported. CHM seems to be an effective and safe therapy option to treat proteinuric patients with DN, suggesting that further study of CHM in the treatment of DN is warranted in rigorously designed, multicentre, large-scale trials with higher quality worldwide.
基金：
NSFC-Guangdong joint
found (no. U1132001), the National Natural Science Foundation
of China (no. 81173146), and the State Administration of
Traditional Chinese Medicine (no. JDZX2012013).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|3 区医学
小类|2 区全科医学与补充医学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity, Guangzhou, Guangdong 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Traditional ChineseMedicine,NanfangHospital, SouthernMedicalUniversity, Guangzhou, Guangdong 510515, China[2]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
推荐引用方式(GB/T 7714)：
Ya Xiao,Yanyan Liu,Keqiang Yu,et al.The effect of chinese herbal medicine on albuminuria levels in patients with diabetic nephropathy: a systematic review and meta-analysis.[J].Evidence-based complementary and alternative medicine : eCAM.2013,2013:937549.doi:10.1155/2013/937549.
APA：
Ya Xiao,Yanyan Liu,Keqiang Yu,Lin Zhou,Jianlu Bi...&Xiaoshan Zhao.(2013).The effect of chinese herbal medicine on albuminuria levels in patients with diabetic nephropathy: a systematic review and meta-analysis..Evidence-based complementary and alternative medicine : eCAM,2013,
MLA：
Ya Xiao,et al."The effect of chinese herbal medicine on albuminuria levels in patients with diabetic nephropathy: a systematic review and meta-analysis.".Evidence-based complementary and alternative medicine : eCAM 2013.(2013):937549
