Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients.
机构:[1]Department of Liver Disease, Shenzhen Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, 518033, China.广州中医药大学深圳医院深圳市康宁医院深圳医学信息中心
To observe the efficacy of ursodeoxycholic acid (UDCA) combined with Tongdan: Decoction () on immunological indices and histopathological changes in patients with primary biliary cirrhosis (PBC) of IIor III histological stage.
Sixty PBC patients were assigned randomly and equally: to the control group treated with UDCA alone and the treatment group treated with UDCA combined with Tongdan Decoction. The immunological indices and histopathological changes were detected before and after 24-week treatment, and the follow-up lasted for 1-3 years.
After 24-week treatment, CD4(+)CD28(-) in the peripheral blood was lowered and CD4(+)CD25(+) was increased in both groups, and better effect was shown in the treatment group (P<0.01). The levels of IgM, IgG, and IgA decreased markedly after 96-week treatment in the treatment group (P< 0.05, P< 0.01), while in the control group, only the latter two showed significant decrease after 148 week (all P<0.05). At the end of the 3-year follow-up, the medians of histopathological <inflammation grading and fibrosis staging declined to a lower rank, and the effect on inflammation was superior in the treatment group to the control group shown by non-parameters Wilcoxon paired symbols test ( Z=2.761,P=0.006).
Combined therapy of Tongdan Decoction and UDCA showed a better therapeutic effect: than UDCA monotherapy on PBC, especially in improving immunological indices and histopathological hepatic changes.
第一作者机构:[1]Department of Liver Disease, Shenzhen Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, 518033, China.
推荐引用方式(GB/T 7714):
Tong Guang-Dong,Tang Hai-Hong,Wei Chun-Shan,et al.Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients.[J].CHINESE JOURNAL OF INTEGRATIVE MEDICINE.2012,18(1):16-22.doi:10.1007/s11655-0112-0962-9.
APA:
Tong Guang-Dong,Tang Hai-Hong,Wei Chun-Shan,Chen Ying-Jie,He Jin-Song...&Zhou Da-Qiao.(2012).Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients..CHINESE JOURNAL OF INTEGRATIVE MEDICINE,18,(1)
MLA:
Tong Guang-Dong,et al."Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients.".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 18..1(2012):16-22