机构：[1]Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China[3]Yuebei People’s Hospital, Guangdong, Shaoguan 512026, China
Buyang Huanwu decoction (BYHWD) is a well-known and canonical Chinese medicine formula from "Correction on Errors in Medical Classics" in Qing dynasty. Here, we show that BYHWD could alleviate the ventricular remodeling induced by left anterior descending (LAD) artery ligation in rats. BYHWD treatment (18 g/kg/day) decreased heart weight/body weight (HW/BW), left ventricle (LV) dimension at end diastole (LVDd) and increased LV ejection fraction (LVEF) and LV fractional shortening (LVFS) significantly compared to model group at the end of 12 weeks. The collagen volume of BYHWD group was more significantly decreased than that of model group. Proteomic analysis showed that atrial natriuretic factor (ANF) was downregulated; heat shock protein beta-6 (HSPB6) and peroxiredoxin-6 (PRDX6) were upregulated in BYHWD-treated group among successfully identified proteins. The apoptotic index (AI) was reduced by BYHWD accompanied by decreased expression of Bax and caspase 3 activity, increased Bcl-2/Bax ratio, and phosphorylation of HSPB6 compared to that of model group. Taken together, these results suggest that BYHWD can alleviate ventricular remodeling induced by LAD artery ligation. The antiremodeling effects of BYHWD are conferred by decreasing AI through affecting multiple targets including increased Bcl-2/Bax ratio and decreased caspase 3 activity that might be via upregulated PRDX6, phosphorylation of HSPB6 and subsequently reduction of ANF.
基金：
National Science Foundation
of China (no. 30973850, 81173459), Planned Science,
Technology Project of Guangdong Province, China (no.2010B060500009), and Administration of Traditional Chinese
Medicine of Guangdong Province, China (no. 101002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2011]版：
大类|3 区医学
小类|2 区全科医学与补充医学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China
共同第一作者：
通讯作者：
通讯机构：[1]Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou 510515, China[2]The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangdong, Guangzhou 510515, China
推荐引用方式(GB/T 7714)：
Zhou Ying Chun,Liu Bin,Li Ying Jia,et al.Effects of buyang huanwu decoction on ventricular remodeling and differential protein profile in a rat model of myocardial infarction.[J].Evidence-based complementary and alternative medicine : eCAM.2012,2012:385247.doi:10.1155/2012/385247.
APA：
Zhou Ying Chun,Liu Bin,Li Ying Jia,Jing Lin Lin,Wen Ge...&Sun Xue Gang.(2012).Effects of buyang huanwu decoction on ventricular remodeling and differential protein profile in a rat model of myocardial infarction..Evidence-based complementary and alternative medicine : eCAM,2012,
MLA：
Zhou Ying Chun,et al."Effects of buyang huanwu decoction on ventricular remodeling and differential protein profile in a rat model of myocardial infarction.".Evidence-based complementary and alternative medicine : eCAM 2012.(2012):385247
