To observe the clinical effect of Yugengtongyu Decoction (YGTY) in treatment of coronary heart disease (CHD) with Qi deficiency, Blood stasis and phlegm stagnancy type and Qi deficiency and Blood stasis type. Patients were divided into two groups, 45 cases in the YGTY group and 38 cases in the control group. In alleviating angina pectoris and improving symptom of CHD, the serum total cholesterol (TC), serum triglyceride (TG) were determined before and after treatment. The total effective rate of spontaneous angina pectoris were significantly better in the treated group than those in the control group (P < 0.005). In improving symptom of CHD were significantly better in the treated group than those in the control group (P < 0.005), and it was better the type of Qi deficiency, Blood stasis and phlegm stagnancy than type of Qi deficiency and Blood stasis in treated group (P < 0.05). TC of the treated group was lowered markedly after treatment, as compared with that before treatment, the difference was significant (P < 0.005). YGTY was effective for alleviating angina pectoris and improving symptom of CHD. It is best for the type of Qi deficiency, Blood stasis and phlegm stagnancy. It also has regulatory effect on the blood lipid.