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Effect of faeces trogopterorum extract B1 on the experimental gastric ulcer and gastric secretion in rats.

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机构: [1]Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
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To study the effects of extracts B1, B2, and B3 from faeces trogopterorum on the experimental gastric ulcer in rats. Two different animal models of gastric ulcers were used in this experiment: Shay's model (n = 72) and the reserpine-induced ulcer model (n = 76). The total volume and the pH of the gastric juices were recorded. The lesion scores of gastric mucosa were also recorded. The lesion scores of gastric mucosa in the Shay's model of animals in the WLZ-B1 groups treated with either 40 g/kg or 80 g/kg were 8.6 ± 10.8 and 1.6 ± 1.9 respectively, which were lower than that of the 0.9% NaCl control group (47.0 ± 31.4, P < 0.05, P < 0.01). The lesion scores for the 80 g/kg group was lower compared to those of the Ran group (20.5 ± 16.4, P < 0.01). The pH of the gastric juices of the 80 g/kg group (3.425 ± 0.143) was higher than that of the 0.9% NaCl group (2.836 ± 0.632, P < 0.05). In the reserpine model, the lesion score of the 40 g/kg group of the WLZ-B1 (20.7 ± 16.5) was also lower than that of the 0.9% NaCl control group (76.3 ± 50.6, P < 0.05). B1 is the most effective of the three sections in inhibiting gastric secretion, protecting gastric mucosa and preventing experimental ulceration.

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大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
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第一作者机构: [1]Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University of Medical Seiences, Guangzhou 510120, Guangdong Province, China.
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