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Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus-related acute liver failure (Open Access)

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Huadi Chen[1,2,3] * ; Wenting Zhao[4] * ; Yixi Zhang[5] * ; Yiwen Guo[1,2,3] ; Weixin Luo[1,2,3] ; Xiaobo Wang[1,2,3] ; Yu Nie[1,2,3] ; Maodong Ye[1,2,3] ; Changjun Huang[1,2,3] ; Dongping Wang[1,2,3] ; Maogen Chen[1,2,3,*1,*2,*3] ; Xiaoshun He[1,2,3,*1,*2,*3] ; Qiang Zhao[1,2,3,*1,*2,*3] ;
机构： [1]Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [2]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China [3]Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China [4]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China [5]Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1111/jcmm.15561
ISSN：

关键词： bioinformatics analysis HBV-ALF immune inflammation WGCNA

摘要：
Acute liver failure (ALF) caused by hepatitis B virus (HBV) is common type of liver failure in the world, with high morbidity and mortality rates. However, the prevalence, genetic background and factors determining the development of HBV-related ALF are rarely studied. In this study, we examined three Gene Expression Omnibus (GEO) data sets by bioinformatics analysis to identify differentially expressed genes (DEGs), key biological processes and pathways. Immune infiltration analysis showed high immune cells infiltration in HBV-related ALF tissue. We then confirmed natural killer cells and macrophages infiltration in clinical samples by immunohistochemistry assay, implying these cells play a significant role in HBV-ALF. We found 1277 genes were co-up-regulated and that 1082 genes were co-down-regulated in the 3 data sets. Inflammation-related pathways were enriched in the co-up-regulated genes and synthetic metabolic pathways were enriched in the co-down-regulated genes. WGCNA also revealed a key module enriching in immune inflammation response and identified 10 hub genes, differentially expressed in an independent data set. In conclusion, we identified fierce immune inflammatory response to elucidate the immune-driven mechanism of HBV-ALF and 10 hub genes based on gene expression profiles. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd

基金：
Supported by grants as follows: National Natural Science Foundation of China (81570587, 81700557, 81401324 and 81770410), the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007 and 2017B030314018), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010), and Science and Technology Program of Guangzhou (201704020150), the Natural Science Foundations of Guangdong province (2016A030310141, 2020A1515010091 and 2020A1515011557) and Young Teachers Training Project of Sun Yat-sen University (K0401068).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 3 区 细胞生物学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 细胞生物学 3 区 医学：研究与实验
JCR分区：
出版当年[2018]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 CELL BIOLOGY
最新[2024]版：
Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2024版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [2]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China [3]Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China
共同第一作者：
通讯作者：
通讯机构： [1]Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [2]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China [3]Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China [*1]Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou 510080,China [*2]Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China [*3]Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Huadi Chen,Wenting Zhao,Yixi Zhang,et al.Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus-related acute liver failure (Open Access)[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2020,24(17):9798-9809.doi:10.1111/jcmm.15561.
APA：
Huadi Chen,Wenting Zhao,Yixi Zhang,Yiwen Guo,Weixin Luo...&Qiang Zhao.(2020).Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus-related acute liver failure (Open Access).JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,24,(17)
MLA：
Huadi Chen,et al."Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus-related acute liver failure (Open Access)".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 24..17(2020):9798-9809

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