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Rapid Development of Targeting circRNAs in Cardiovascular Diseases.

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机构: [1]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of SingleCell Technology and Application, Guangzhou 510000, Guangdong Province, China [2]Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University,Foshan 510000, Guangdong Province, China [3]Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada [4]College of Traditional ChineseMedicine, Southern Medical University, Guangzhou 510000, Guangdong Province, China [5]Basic Medical College, Xiangnan University, Chenzhou 523000, China [6]Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada [7]Department of Laboratory Medicine and Pathobiology,University of Toronto, Toronto, ON M5S 1A1, Canada [8]Jiangxi Medical College, Nanchang University, Nanchang 330000, Nanchang, Jiangxi Province, China
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Circular RNAs (circRNAs) are circularized, single-stranded RNAs that are covalently linked. With their abundance in tissues and developmental stage-specific expression, circRNAs participate in a variety of physiological and pathological processes. In this review, we discuss the development of circRNAs used as biomarkers and therapeutic targets for cardiovascular diseases (CVDs), focusing on recent discoveries and applications of exosomal circRNAs that highlight opportunities and challenges. Some studies have identified a spectrum of circRNAs that are differentially expressed in CVDs, while other studies further manipulated specific circRNA expression and showed an ameliorated pathogenic state such as ischemic injury, hypertrophy, and cardiac fibrosis. Studies and applications of circRNAs are being rapidly developed. We expect to see clinical use of circRNAs as biomarkers and targets for disease treatment in the near future. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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出版当年[2019]版:
大类 | 2 区 医学
小类 | 2 区 医学:研究与实验
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 医学:研究与实验
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第一作者机构: [1]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of SingleCell Technology and Application, Guangzhou 510000, Guangdong Province, China [2]Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University,Foshan 510000, Guangdong Province, China [6]Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada [*2]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 705, Life Science Building, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China
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通讯作者:
通讯机构: [1]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of SingleCell Technology and Application, Guangzhou 510000, Guangdong Province, China [2]Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University,Foshan 510000, Guangdong Province, China [6]Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada [7]Department of Laboratory Medicine and Pathobiology,University of Toronto, Toronto, ON M5S 1A1, Canada [*1]Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, S110, S-Wing Research Building, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. [*2]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 705, Life Science Building, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China [*3]Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China.
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