详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Relationship between obesity and risk of major osteoporotic fracture in postmenopausal women: taking frailty into consideration.

10| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China. [2]Department of Health research methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada. [3]Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [4]Departments of Medicine and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada. [5]Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [6]Department of Orthopaedics and Traumatology, Guangdong Second Provincial General Hospital, Guangzhou, China. [7]Department of Endocrinology, Guangdong Second Provincial General Hospital, Guangzhou, China. [8]Department of Orthopedics No.2 (Spinal Surgery), Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, China.

出处：

DOI：

ISSN：

摘要：

The role of obesity in fracture risk remains to be uncertain and inconclusive in postmenopausal women. Our study aimed to assess the relationship between obesity and risk of major osteoporotic fracture (MOF; i.e., a clinical fracture of upper arm or shoulder, hip, spine, or wrist) in postmenopausal women, after taking frailty into consideration. We used the data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) 5-year Hamilton cohort for this study. Frailty was measured by a frailty index (FI) of deficit accumulation at baseline. We incorporated an interaction term (obesity x FI) in the Cox proportional hazards regression model. We included 3985 women (mean age: 69.4 years) for analyses, among which 29% were obese (n = 1118). There were 200 (5.02%) MOF events documented during follow-up: 48 (4.29%) in obese women and 152 (5.65%) in the nonobese group. Significant relationships between obesity, frailty and MOF risk were found: HR = 0.72 (95% CI: 0.67-0.78) for those with an FI of zero regarding MOF risk among obese women, and HR = 1.34 (95% CI: 1.11-1.62) per-SD increase in the FI among nonobese women. The interaction term was also significant: HR = 1.16 (95% CI: 1.02-1.34) per-SD increase in the FI among obese women. Increased HRs were found with higher FIs regarding the relationship between obesity and MOF risk, indicating increasing frailty attenuated the protective effect of obesity. For example, while the HR for obesity and MOF risk among those who were not frail (FI = 0) was 0.72 (95% CI: 0.67-0.78), among those who were very frail (FI = 0.70), the HR was 0.91 (95% CI: 0.85-0.98). To conclude, after taking frailty into consideration, obesity was significantly associated with decreased risk of MOF in postmenopausal women among those who were not frail; however increasing frailty attenuated this protective effect of obesity. Evaluating frailty status may aid in understanding of the complex relationship between obesity and fracture risk. This article is protected by copyright. All rights reserved.

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2019]版：

大类 | 2 区

医学

小类 | 2 区内分泌学与代谢

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区内分泌学与代谢

JCR分区：

出版当年[2018]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 5.1 最新[2023版] 5.8 最新五年平均 5.711 出版当年[2018版] 6.242 出版当年五年平均 6.314 出版前一年[2017版] 5.854 出版后一年[2019版]

第一作者：

第一作者机构： [1]Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China. [2]Department of Health research methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada. [*1]Guangdong Second Provincial General Hospital, 466 Newport Middle Road, Haizhu District, Guangzhou 510317, Guangdong Province, China

共同第一作者：

通讯作者：

通讯机构： [1]Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China. [2]Department of Health research methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada. [8]Department of Orthopedics No.2 (Spinal Surgery), Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, China. [*1]Guangdong Second Provincial General Hospital, 466 Newport Middle Road, Haizhu District, Guangzhou 510317, Guangdong Province, China [*2]Department of Orthopedics No. 2 (Spinal Surgery), Guangdong Provincial Hospital of Chinese Medicine, 53 Jingle Road, Zhuhai, 519015, Guangdong Province, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：