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Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases.

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收录情况： ◇ SCIE

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机构： [1]Center for Pathophysiology, School of BasicMedicine and Clinical Pharmacy,Pharmaceutical University, Nanjing, JiangsuProvince, China [2]Department of Endocrinology, JiangsuProvince Hospital of Traditional ChineseMedicine, The Affiliated Hospital of NanjingUniversity of Chinese Medicine, Nanjing,Jiangsu Province, China [3]Suzhong Pharmaceutical Research Institute,Nanjing, Jiangsu Province, China [4]Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University, Nanjing,Jiangsu Province, China [5]Department of Pharmacology, China Pharmaceutical University, Nanjing, JiangsuProvince, China [6]Department of Nephrology, Second People'sHospital, First Affiliated Hospital of ShenzhenUniversity, Shenzhen, Guangdong Province,China

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摘要：

Abelmoschus manihot, also called as "Huangkui" in Chinese, is an annual flowering herb plant in the family of Malvaceae. As a traditional Chinese medicine, the ethanol extract of the flower in Abelmoschus manihot is made as Huangkui capsule and has been used for medication of the patients with kidney diseases. Its efficacy in clinical symptoms is mainly improving renal function and reducing proteinuria among the patients with chronic kidney disease, diabetic kidney disease or IgA nephropathy. The possible mechanism of Huangkui capsule treatment in kidney diseases may include reducing inflammation and anti-oxidative stress, improving immune response, protecting renal tubular epithelial cells, ameliorating podocyte apoptosis, glomerulosclerosis and mesangial proliferation, as well as inhibiting renal fibrosis. In this review, we first described chemical constituents and pharmacokinetic characteristics in ethanol extract of the flower of Abelmoschus manihot. We then summarized the clinical and epidemiological relevancies of kidney diseases particularly in the mainland of China and discussed the possible molecular mechanisms of Huangkui capsule in the treatment of kidney diseases. Finally, we prospected further research on cellular and molecular mechanisms and application of this Chinese natural medicine in kidney diseases. © 2020 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区药学 3 区药物化学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药物化学 2 区药学

JCR分区：

出版当年[2019]版：

Q1 PHARMACOLOGY & PHARMACY Q1 CHEMISTRY, MEDICINAL

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 6.1 最新[2023版] 7 最新五年平均 4.087 出版当年[2019版] 3.971 出版当年五年平均 3.766 出版前一年[2018版] 5.882 出版后一年[2020版]

第一作者：

第一作者机构： [1]Center for Pathophysiology, School of BasicMedicine and Clinical Pharmacy,Pharmaceutical University, Nanjing, JiangsuProvince, China [2]Department of Endocrinology, JiangsuProvince Hospital of Traditional ChineseMedicine, The Affiliated Hospital of NanjingUniversity of Chinese Medicine, Nanjing,Jiangsu Province, China

通讯作者：

通讯机构： [1]Center for Pathophysiology, School of BasicMedicine and Clinical Pharmacy,Pharmaceutical University, Nanjing, JiangsuProvince, China [*1]Center for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang 24, Nanjing, Jiangsu 210009, China.

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