机构：[1]Bao'an Hospital of TCM Affiliated with Guangzhou University of TCM, Shenzhen Guangdong Province, China.[2]Chinese Traditional Medicine Hospital of Shenzhen City, Shenzhen Guangdong Province, China.[3]Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi City, Heilongjiang Province, China.
Ischemic stroke is a common cause of death and disability throughout the world. We aimed to evaluate the association between polymorphisms in TBXA2R (rs4523, rs768963, rs1131882), P2Y12 (rs204693), ADD1 (rs4961) and risk of ischemic stroke.
A comprehensive retrieval with the databases of Pubmed, Embase, CENTRAL, CNKI and Wan fang data was conducted. The deadline was February 1, 2019. Pooled ORs and 95% CIs were calculated by using the Z-test. Heterogeneity between the included studies was tested using the I2 method. Begg's funnel plot and Egger's linear regression were used to evaluate the publication bias. Software STATA 12.0 (StataCorp, College Station, TX, USA) was used for the meta-analysis and 26 studies with 5,776 cases and 8,025 controls were included.
The results indicated significantly higher risk of ischemic stroke associated with TBXA2R variant rs768963 in all genetic models (C vs T: OR=1.27, 95% CI=1.13-1.42, P.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Bao'an Hospital of TCM Affiliated with Guangzhou University of TCM, Shenzhen Guangdong Province, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Liang Xuesong,Zhou You,Li Shuoxi.Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.[J].CLINICAL AND INVESTIGATIVE MEDICINE.2020,43(3):E33-43.doi:10.25011/cim.v43i3.34597.
APA：
Liang Xuesong,Zhou You&Li Shuoxi.(2020).Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis..CLINICAL AND INVESTIGATIVE MEDICINE,43,(3)
MLA：
Liang Xuesong,et al."Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.".CLINICAL AND INVESTIGATIVE MEDICINE 43..3(2020):E33-43
