机构：[1]Intensive Care Laboratory, Guangdong Province Hospital of Chinese Medicine, 2nd affiliated hospital of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[2]Department of Cardiology, The Second Clinical Medical School, Yangzhou University, Yangzhou, China
OBJECTIVE: Sepsis is a serious systemic disorder with high mortality, frequently accompanied with the elevated circulating catecholamines that further increase the risk of developing ventricular tachyarrhythmia and fibrillation. However, the direct effect of sepsis itself on ventricular arrhythmia remains unclear. This study aims to evaluate the effects of sepsis and catecholamine on cardiac action potential and arrhythmogenicity. METHODS: We incorporated into a computer simulation model of ventricular action potential (AP) to evaluate the effects of sepsis (lipopolysaccharides stimulation and hypoxia) on the L-type Ca2+ channel current (ICa-L), the ATP-dependent potassium current (IK(ATP)), the slow and rapid components of the delayed rectifier K+-current (IKs and IKr), and detect the APs in the absence and presence of beta-adrenergic receptor (beta-AR) stimulation. RESULTS: Sepsis reduced AP duration rate-dependently, but did not alter the AP configuration. In the presence of beta-AR stimulation, sepsis prolonged the AP and induced the early afterdepolarizations (EADs) and spontaneous tachycardia. The above cellular electrophysiological mechanism was supported by the clinical electrocardiogram recorded in a sepsis patient. CONCLUSIONS: Beta-AR stimulation was essential for the occurrence of EADs in the sepsis model. EADs occurred predominantly due to an increased sensitivity of ICa-L to beta-AR stimulation during sepsis. IK (ATP) played an important role in preventing EADs and spontaneous tachycardia in sepsis.
基金：
This study was supported by National Scientific Funding of Guangdong (No.S20120410008010, to J Qi), Guangdong Province Medical Research Foundation(No, A2013235, to J Qi) and National Scientific Funding of China (No. 81173439, to M Zhang), the Project of Prospering Health by Science and Education in Jiangsu Province (No. RC2011045, to K Gong) and Jiangsu “333 Project” (No. BRA2012095,to K Gong).
基金编号：No.S20120410008010, to J Qi
语种：
外文
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区心脏和心血管系统
最新[2025]版：
无
第一作者：
第一作者机构：[1]Intensive Care Laboratory, Guangdong Province Hospital of Chinese Medicine, 2nd affiliated hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
通讯机构：[1]Intensive Care Laboratory, Guangdong Province Hospital of Chinese Medicine, 2nd affiliated hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[2]Department of Cardiology, The Second Clinical Medical School, Yangzhou University, Yangzhou, China[*1]Intensive Care Laboratory, Guangdong Province Hospital of Chinese Medicine, 101 Dade Road, Yuexiu District, Guangzhou, China[*2]Department of Cardiology, The Second Clinical Medical School, Yangzhou University, China
推荐引用方式(GB/T 7714)：
Jianyong Qi,Mingxing Chen,Yanhong Huo,et al.Cardiac arrhythmia in sepsis - A simulation study[J].Experimental and Clinical Cardiology.2014,20(6):
APA：
Jianyong Qi,Mingxing Chen,Yanhong Huo,Juan Yu,MinzhouZhang&Kaizheng Gong.(2014).Cardiac arrhythmia in sepsis - A simulation study.Experimental and Clinical Cardiology,20,(6)
MLA：
Jianyong Qi,et al."Cardiac arrhythmia in sepsis - A simulation study".Experimental and Clinical Cardiology 20..6(2014)
