A quantitative prediction method for TCM syndrome element identification based on ensemble learning is proposed. Four comparative experiments were designed. Firstly, eight mainstream learners were used to perform the regression prediction based on the symptoms and syndrome values using the quantitative data of clinical TCM syndrome differentiation. Secondly, five learners with excellent prediction performance were selected to design three integrated learners including homogeneous static integrated learner, heterogeneous static integrated learner and dynamic one, where the heterogeneous integrator used as the learner weight coefficient to weigh up its significance. By comparing the MAE, MSE and R2 of the three ensemble learning methods in the four syndrome differentiation groups, it is found that the regression effect based on heterogeneous ensemble learning is the best (MAE: 0.012, MSE: 4.55E-04, R2: 0.733), and the principal sequential evaluation of syndrome elements gained relatively matching degree, which had proved the feasibility of application on the method proposed in the quantitative prediction of clinical TCM syndromes. Copyright © 2020 Inderscience Enterprises Ltd.