机构：[1]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China[2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[3]Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong[4]Shanghai GuangHua Hospital of Integrated Traditional Chinese and Western Medicine, Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai, China
As an important pathological result of rheumatoid arthritis (RA), bone destruction will lead to joint injury and dysfunction. The imbalance of bone metabolism caused by increased osteoclast activities and decreased osteoblast activities is the main cause of bone destruction in RA. MicroRNAs (MiRNAs) play an important role in regulating bone metabolic network. Recent studies have shown that miRNAs play indispensable roles in the occurrence and development of bone-related diseases including RA. In this paper, the role of miRNAs in regulating bone destruction of RA in recent years, especially the differentiation and activities of osteoclast and osteoblast, is reviewed. Our results will not only help provide ideas for further studies on miRNAs' roles in regulating bone destruction, but give candidate targets for miRNAs-based drugs research in bone destruction therapy of RA as well.
基金：
National Key Research and Development Program of China [2018YFC1705205]
第一作者机构：[1]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China[2]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
通讯机构：[3]Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong[4]Shanghai GuangHua Hospital of Integrated Traditional Chinese and Western Medicine, Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai, China
推荐引用方式(GB/T 7714)：
Zhao Hanxiao,Lu Aiping,He Xiaojuan.Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2020,8:doi:10.3389/fcell.2020.600867.
APA：
Zhao, Hanxiao,Lu, Aiping&He, Xiaojuan.(2020).Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,8,
MLA：
Zhao, Hanxiao,et al."Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 8.(2020)
