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Targeting neuroinflammation: The therapeutic potential of omega-3 PUFAs in substance abuse.

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收录情况： ◇ SCIE ◇ SSCI

作者：

机构： [1]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China. [2]College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. [3]Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China. [4]Xinxiang Key Laboratory of Forensic Toxicology, School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China. [5]Department of Metabolic Endocrinology, Shenzhen Longhua District Central Hospital, Shenzhen, China. [6]Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China

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关键词： Astrocytes Microglia Neuroinflammation Substance abuse ω-3 PUFAs

摘要：

Substance abuse is a chronic relapsing disorder that results in serious health and socioeconomic issues worldwide. Addictive drugs induce long-lasting morphologic and functional changes in brain circuits and account for the formation of compulsive drug-seeking and drug-taking behaviors. Yet, there remains a lack of reliable therapy. In recent years, accumulating evidence indicated that neuroinflammation was implicated in the development of drug addiction. Findings from both our and other laboratories suggest that ω-3 polyunsaturated fatty acids (PUFAs) are effective in treating neuroinflammation-related mental diseases, and indicate that they could exert positive effects in treating drug addiction. Thus, in the present review, we summarized and evaluated recently published articles reporting the neuroinflammation mechanism in drug addiction and the immune regulatory ability of ω-3 PUFAs. We also sought to identify some of the challenges ahead in the translation of ω-3 PUFAs into addiction treatment. Copyright © 2020 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区营养学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区营养学

JCR分区：

出版当年[2019]版：

Q2 NUTRITION & DIETETICS

最新[2023]版：

Q2 NUTRITION & DIETETICS

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 3.639 出版当年[2019版] 4.118 出版当年五年平均 3.591 出版前一年[2018版] 4.008 出版后一年[2020版]

第一作者：

第一作者机构： [1]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China.

通讯作者：

通讯机构： [1]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China. [6]Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China [*1]Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China [*2]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Hunan, China.

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Targeting neuroinflammation: The therapeutic potential of omega-3 PUFAs in substance abuse.

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