机构:[a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.广东省中医院[b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China广东省中医院[c]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 and 70 mg kg-1, orally administered for 4 weeks) was administered to 7-month-old aging mice (senescence-accelerated mouse prone 8 mice). As a result, it was found that quercetin could improve spatial learning and memory impairment displayed by aging mice in the Morris water maze. The results of immunoblotting reflected the protein expressions of the longevity factor (sirtuin1), inflammasomes (NLRP3 and ASC), synaptic marker (PSD95) and neurotrophic factors (BDNF and NGF) in the hippocampus of the brain. It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1β and IL-18). In addition, quercetin could reduce the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in the hippocampus of aging mice. Current data indicated that quercetin might improve neuroinflammation in aging mice by regulating the Sirtuin1/NLRP3 pathway.
基金:
This work was supported by the Guangdong Provincial Key
Laboratory of Research on Emergency in TCM
(2017B030314176).
第一作者机构:[a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.[b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China[c]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
共同第一作者:
通讯作者:
通讯机构:[a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.[b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
推荐引用方式(GB/T 7714):
Han Li,Fa-Jun Chen,Wei-Lin Yang,et al.Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.[J].FOOD & FUNCTION.2021,12(2):717-725.doi:10.1039/d0fo01900c.
APA:
Han Li,Fa-Jun Chen,Wei-Lin Yang,Han-Zi Qiao&Shi-Jie Zhang.(2021).Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation..FOOD & FUNCTION,12,(2)
MLA:
Han Li,et al."Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.".FOOD & FUNCTION 12..2(2021):717-725