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Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.

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收录情况: ◇ SCIE ◇ EI

机构: [a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [c]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 and 70 mg kg-1, orally administered for 4 weeks) was administered to 7-month-old aging mice (senescence-accelerated mouse prone 8 mice). As a result, it was found that quercetin could improve spatial learning and memory impairment displayed by aging mice in the Morris water maze. The results of immunoblotting reflected the protein expressions of the longevity factor (sirtuin1), inflammasomes (NLRP3 and ASC), synaptic marker (PSD95) and neurotrophic factors (BDNF and NGF) in the hippocampus of the brain. It indicated that the intervention of quercetin could increase the expression of sirtuin1 and prevent neuroinflammation, which was evident from the decrease in the protein levels of the astrocyte marker (GFAP) and inflammatory factors (cleaved-caspase 1, IL-1β and IL-18). In addition, quercetin could reduce the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in the hippocampus of aging mice. Current data indicated that quercetin might improve neuroinflammation in aging mice by regulating the Sirtuin1/NLRP3 pathway.

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出版当年[2020]版:
大类 | 1 区 农林科学
小类 | 2 区 食品科技 3 区 生化与分子生物学
最新[2025]版:
大类 | 2 区 农林科学
小类 | 2 区 生化与分子生物学 2 区 食品科技
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出版当年[2019]版:
Q1 FOOD SCIENCE & TECHNOLOGY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版:
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 FOOD SCIENCE & TECHNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China [c]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
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通讯作者:
通讯机构: [a]Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [b]Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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