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Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients.

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机构: [1]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China, [2]Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China, [3]Department of Medical Imaging, Traditional Chinese Medicine-Integrated Hospital of Southern Medical University, Guangzhou, China, [4]Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China
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关键词: ankylosing spondylitis gray matter volume voxel-based morphometry pain disease duration

摘要:
Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients. The purpose of the present study was to describe brain gray matter abnormalities associated with AS pain. A total of 61 AS patients and 52 healthy controls (HCs) were included in this study. Using voxel-based morphometrics, we detected abnormal gray matter volume in AS patients. Based on the voxel-wise analysis, the gray matter volume in the left putamen of the AS group was increased significantly compared with that of the HC group. In addition, we found that the gray matter volume of the left putamen was positively correlated with the duration of AS and total back pain scores, whereas it was not significantly correlated with Bath Ankylosing Spondylitis Disease Activity Index scores, C-reactive protein, or erythrocyte sedimentation rate in AS patients. Taken together, our findings improve our understanding of the neural substrates of pain in AS and provide evidence of AS-related neurological impairment. Hence, further investigation of the pathophysiology of the left putamen in AS is warranted. Copyright © 2020 Hua, Wang, Lan, Li, Zhao, Wang, Li, Ma, Li, Fu, Yin, Liu, Fang, Li and Jiang.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
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第一作者机构: [1]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China, [2]Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China,
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通讯作者:
通讯机构: [1]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China, [2]Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China,
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