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Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology.

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机构: [1]Guangdong Provincial Key Laboratory ofMalignant Tumor Epigenetics and GeneRegulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, People'sRepublic of China [2]Department of TraditionalChinese Medicine, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou,People’s Republic of China [3]Department ofThoracic Surgery, Sun Yat-sen MemorialHospital, Sun Yat-sen University, Guangzhou,People's Republic of China [4]Department ofHepatobiliary Surgery, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou,People’s Republic of China [5]Sun Yat-SenUniversity Zhongshan School of Medicine,Guangzhou, People’s Republic of China
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Gastric cancer was still one of the commonly diagnosed cancer types and the third-most common cause of cancer-related death in the world. Gentiopicroside, which is extracted from the Gentianella acuta, is commonly used in both traditional treatment and modern clinical care; therefore, its anticancer effects have been attracted more attention. However, the systematic analysis of action mechanism of Gentiopicroside on gastric cancer (GC) has not yet been carried out. A network pharmacology-based strategy combined with molecular docking studies and in vitro validation was employed to investigate potential targets and molecular mechanism of Gentiopicroside against GC. Potential targets of Gentiopicroside, as well as related genes of GC, were acquired from public databases. Potential targets, and signaling pathways were determined through bioinformatic analysis, including protein-protein interaction (PPI), the Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, molecular docking and cell experiments were performed to further verify the above findings. Our findings revealed that the anticancer activity of Gentiopicroside potentially involves 53 putative identified target genes. In addition, GO, KEGG, and network analyses revealed that these targets were associated with cell proliferation, metabolic process, and other physiological processes. Furthermore, we have proved that critical compound affected the expression of CCND1, CCNE1, p-AKT and p-P38 at protein levels. These findings provide an overview of the anticancer action of Gentiopicroside from a network perspective; meanwhile, it might also set an example for future studies of other materials used in traditional Chinese medicine (TCM). This study comprehensively illuminated the potential targets and molecular mechanism of Gentiopicroside against GC. It also provided a promising approach to uncover the scientific basis and therapeutic mechanism of TCM treating for disease. © 2020 Huang et al.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 药物化学 2 区 药学
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出版当年[2018]版:
Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Guangdong Provincial Key Laboratory ofMalignant Tumor Epigenetics and GeneRegulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, People'sRepublic of China [2]Department of TraditionalChinese Medicine, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou,People’s Republic of China
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通讯机构: [1]Guangdong Provincial Key Laboratory ofMalignant Tumor Epigenetics and GeneRegulation, Sun Yat-sen Memorial Hospital,Sun Yat-sen University, Guangzhou, People'sRepublic of China [2]Department of TraditionalChinese Medicine, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou,People’s Republic of China [4]Department ofHepatobiliary Surgery, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou,People’s Republic of China [*1]Department of Hepatobiliary Surgery, Sun Yat- Sen Memorial Hospital, Sun Yat-Sen University, Yanjiang West Road 107#, Guangzhou 510120, People’s Republic of China [*2]Department of Traditional Chinese Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Yanjiang West Road 107#, Guangzhou 510120, People’s Republic of Chin
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