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Acute toxicity and micronucleus test of conotoxin lt14a in mice.

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机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China [2]National Engineering Research Center of South China Sea Marine Biotechnology, Guangzhou, China [3]Ningxia Key Laboratory for Cerebrocranical Disease, Ningxia Medical University, Yinchuan, China [4]China School of Fundamental Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China [5]Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Changsha, China

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关键词： acute toxicity conopeptide conotoxin lt14a micronucleus test

摘要：

Conotoxins, which target ion channels or neurotransmitter receptors with high specificity, are valuable in drug development for pain, epilepsy and other neurological diseases. However, the toxicology of conotoxins is rarely reported. In this study, we primarily researched parts of the pharmacological and toxicological properties of an analgesic conotoxin lt14a. Three doses of lt14a (1, 5 and 10 mg/kg) could prolong the pentobarbital-induced sleep time of mice and showed no significant effect on the spontaneous locomotor activity of mice. Three doses of lt14a (50, 100 and 200 mg/kg) did not increase micronucleus rate in the micronucleus test. In addition, three doses of lt14a (200, 500 and 1000 mg/kg) showed no pathological change on the heart or brain of mice in the acute toxicity test. The high dose of lt14a (1000 times the effective analgesic dose) had a certain damaging effect on the liver and lung according to serological detection and histopathology. As part of the preclinical studies, our results provide acute toxicity and mutagenicity evaluation of the promising analgesic conotoxin lt14a. © 2021 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区药学 3 区毒理学

最新[2025]版：

大类 | 4 区医学

小类 | 3 区毒理学 4 区药学

第一作者：

第一作者机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China [2]National Engineering Research Center of South China Sea Marine Biotechnology, Guangzhou, China

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通讯作者：

通讯机构： [2]National Engineering Research Center of South China Sea Marine Biotechnology, Guangzhou, China [4]China School of Fundamental Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China [5]Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Changsha, China [*1]China School of Fundamental Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [*2]Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

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